Vascular Disease Prevention (Discontinued) - Volume 5, Issue 3, 2008

Lipoprotein(a), Lp(a), represents a class of lipoproteins characterized by having a single mole of poB100 covalently linked to a single mole of apolipoprotein(a), apo(a), a multikringle structure with close homology to lasminogen. High plasma levels of Lp(a) have been associated with an increased incidence of atherosclerotic cardiovascular disease by mechanisms yet poorly defined. The structural and functional propertie Read More

We review extensive data in patients with coronary heart disease demonstrating the benefits of exercise training (ET) programs with cardiac rehabilitation on various cardiovascular (CV) factors, including exercise capacity, plasma lipids, obesity indices, diabetes mellitus/metabolic syndrome, inflammation, blood rheology, autonomic function, indices of ventricular repolarization dispersion, psychological risk factors, Read More

Internal jugular vein (IJV) thrombosis is exceedingly rare and it is typically the result of head and neck infections or trauma, intravenous drug abuse or long-standing central venous catheters. Malignancies are also a cause of IJV thrombosis. We present a case of bilateral IJV thrombosis in a 48-year-old man. Additional investigations revealed a malignancy of the stomach. Based on a search of the literature, we suggest that patie Read More

Objective: We carried out a retrospective cohort study to examine the influence of personal and disease characteristics at the time of admission on the 30-day mortality of acute myocardial infarction (AMI) among Chinese subjects. Methods: All 1440 patients with transmural AMI admitted to the coronary care unit of a major regional hospital in Hong Kong from 1991 to 2001 were included and followed up for at least 30 days. Cox' Read More

In recent years, the role of C-reactive protein (CRP) in cardiovascular disease has been a lively topic of debate. The reasons for this interest can be summarized as follows. First, CRP has been identified as a powerful cardiovascular risk marker. Second, CRP may not only be a cardiovascular risk marker but also a risk factor, i.e., it may be causally involved in atherogenesis and its sequelae. Third, if it is indeed a cardiovascular risk Read More

Background and objective: Insulin resistance is thought to be central to the pathogenesis of abdominal obesitylinked metabolic syndrome (MetS). Colestimide, a 2-methylimidazole-epichlorohydrin polymer, is a new bile-acidsequestering resin used to lower LDL cholesterol. In recent reports, bile acid-controlled signaling pathways have shown promise as novel drug targets to treat metabolic disorders, such as obesity, type 2 diabe Read More

Unfractionated heparin (UFH) and Low Molecular Weight Heparins (LMWHs) represent the mainstay of agents available for the management of venous and arterial thrombosis. LMWHs represent the agents of choice for the prevention and treatment of venous thromboembolism because they have improved pharmacological and pharmacokinetic advantages. LMWHs are derived from UFH by chemical or enzymatic depoly Read More

Objective: Drug eluting stents have recently been associated with the increased risk of adverse thrombogenic events and/or late luminal loss, which is highly associated with incomplete re-endothelialization. The increased risks behoove the design of alternative delivery modalities and/or drugs that do not compromise the re-endotheliaization process. The objective of the present study is to elucidate the biological mechanism(s) Read More