Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Reviews on Recent Clinical Trials
  4. Volume 20, Issue 2
  5. Article
Volume 20, Issue 2
  • ISSN: 1574-8871
  • E-ISSN: 1876-1038

Abstract

Introduction

Wernicke Encephalopathy (W.E.) is an acute neurological disorder induced by thiamine deficiency. Alcohol abuse is considered to be the leading cause of the disease; however, numerous other conditions, such as malnutrition or cancer, have been identified as potential risk factors.

Case Presentation

Clinical manifestations include a typical triad of mental status alteration, nystagmus, and ataxia and are attributed to damage in brain regions of high thiamine demand. The diagnosis is mainly clinical and further supported by the immediate response of neurological signs to parenteral thiamine administration. Among paraclinical examinations, brain MRI is considered substantial for diagnosis and is supported by the determination of thiamine blood levels.

Conclusion

Non-alcoholic W.E. is trickier to diagnose due to its atypical clinical course and risk factors. We herein describe a case of non-alcoholic W.E. in a woman with colon cancer who gradually developed the classic symptoms of thiamine deficiency.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/rrct/10.2174/0115748871320420241016060051
2024-10-30
2025-06-17

  • From This Site

    /content/journals/rrct/10.2174/0115748871320420241016060051
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. ChandrakumarA. BhardwajA. ’t JongG.W. Review of thiamine deficiency disorders: Wernicke encephalopathy and korsakoff psychosis.J. Basic Clin. Physiol. Pharmacol.201930215316210.1515/jbcpp‑2018‑007530281514
     [Google Scholar]
  2. SlimS. AyedK. TrikiW. BaccarA. BaraketO. RahalK. GanzouiI. BouchouchaS. Gayet-Wernicke’s encephalopathy complicating prolonged parenteral nutrition in patient treated for colonic cancer. A case report –.BMC Nutr.2022818310.1186/s40795‑022‑00585‑w35978449
     [Google Scholar]
  3. OudmanE. WijniaJ.W. OeyM. van DamM. PainterR.C. PostmaA. Wernicke’s encephalopathy in hyperemesis gravidarum: A systematic review.Eur. J. Obstet. Gynecol. Reprod. Biol.2019236849310.1016/j.ejogrb.2019.03.00630889425
     [Google Scholar]
  4. ChoI.J. ChangH.J. LeeK.E. WonH.S. ChoiM.Y. NamE.M. MunY.C. LeeS.N. SeongC.M. A case of wernicke’s encephalopathy following fluorouracil-based chemotherapy.J. Korean Med. Sci.200924474775010.3346/jkms.2009.24.4.74719654964
     [Google Scholar]
  5. FedeliP. Justin DaviesR. CirocchiR. PopivanovG. BruzzoneP. GiustozziM. Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery.Open Med. (Wars.)202015170971310.1515/med‑2020‑021033336027
     [Google Scholar]
  6. WijniaJ.W. A Clinician’s view of wernicke-korsakoff syndrome.J. Clin. Med.20221122675510.3390/jcm1122675536431232
     [Google Scholar]
  7. Pérez-TomásR. Pérez-GuillénI. Lactate in the tumor microenvironment: An essential molecule in cancer progression and treatment.Cancers.20201211324410.3390/cancers1211324433153193
     [Google Scholar]
  8. OudmanE. WijniaJ.W. OeyM.J. van DamM. PostmaA. Wernicke-Korsakoff syndrome despite no alcohol abuse: A summary of systematic reports.J. Neurol. Sci.202142611748210.1016/j.jns.2021.11748234000679
     [Google Scholar]
  9. SechiG. SerraA. Wernicke’s encephalopathy: New clinical settings and recent advances in diagnosis and management.Lancet Neurol.20076544245510.1016/S1474‑4422(07)70104‑717434099
     [Google Scholar]
  10. PearceJ.M.S. Wernicke-korsakoff encephalopathy.Eur. Neurol.2008591-210110410.1159/00010958017934284
     [Google Scholar]
/content/journals/rrct/10.2174/0115748871320420241016060051
Loading
Non-alcoholic Wernicke Encephalopathy in a Young Patient with Adenocarcinoma of the Colon: A Case Report and Review of the Literature
Rev. Recent Clin. Trials 20, 180 (2025); https://doi.org/10.2174/0115748871320420241016060051
/content/journals/rrct/10.2174/0115748871320420241016060051
/content/journals/rrct/10.2174/0115748871320420241016060051
Loading

Data & Media loading...


  • Article Type:     Case Report
Keyword(s): adenocarcinoma; cancer; colon; neurological disorder; thiamine; Wernicke encephalopathy

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test