Recent Patents on Biomarkers (Discontinued) - Volume 5, Issue 1, 2015

Cancer Stem Cells (CSC) comprise a concept proposed in the 1990s in hematopoietic cancers. These cells were considered, by similitude to normal stem cells, to constitute a small pool of self-renewing cells able to maintain a tumor. Due to their quiescence, CSC would be able to avoid chemotherapeutics targeting fast proliferation rates, or radiotherapy, thus being responsible for tumour relapse. Since CSCs have also b Read More

The genetic and epigenetic events appear to control the initiation and progression of cancer. The tenuous link between the environmental, lifestyle factors and genetic influences is being actively researched across the world. Epigenetic changes can control gene expression independent of mutations. The current advances in the cancer therapy are targeting on epigenetic mechanisms such as tumor- specificity of genes, DN Read More

Preeclampsia is a multisystem disorder, pathophysiology of which is still not clear. It is one of the leading causes of maternal and fetal morbidity and mortality. Epigenetic programing is altered during fetal life and postnatal period and after birth, this sceniaro is changed to metabolic disorders of metabolic syndrome complex and this may contribute to future risk of hypertension, DM2, and cardiovascular disease. During (norma Read More

Viruses lack the synthetic machinery, so they hijack the synthetic machinery of host cells to produce proteins; and in this process trigger cancer. Since current therapies are ineffective in dealing with virally induced cancers, a future goal could be to develop vaccines against these tumor viruses. Indeed, a recent patent has demonstrated the utility of host p16 peptide fragments to vaccinate against various HPV induced tu Read More

Polycystic kidney disease (PKD) is characterized by the formation and expansion of fluidfilled cysts within the kidneys, painful renal enlargement and declining kidney function. Often, PKD manifests in other organs, including the liver and pancreas. In addition to cyst formation, interstitial collagen deposition is sometimes observed in both the kidney and the liver. While a diagnosis of PKD may be made using ultrasonograph Read More

We examined the prognostic performance of measurements of cTnT concentrations at admission compared to discharge, in predicting major cardiovascular events during hospital admission and at six months follow-up. Methods and Results: The study population comprised 1351 patients with AMI and a mean age of 57.5 + 11.4 years, of whom 66% were males. Cardiac TnT was measured on admission, 24 hours, and at di Read More