Recent Patents on Biomarkers (Discontinued) - Volume 4, Issue 1, 2014

Osteoarthritis is a multifactorial joint disease affecting millions of patients all around the world. Some inflammatory mediators as interleukin-1 beta and tumor necrosis factor-alpha, among others, are involved in stimulating the metalloproteinases production in the osteoarthritis disease process. These enzymes degrade all the articular cartilage extracellular matrix components; such as collagen, aggrecan and non-collagen protei Read More

Background: Hepatitis C virus is a serious global health problem affecting more than 170 million patients who are at risk of developing liver cirrhosis and/or hepatocellular carcinoma. Egypt has the highest prevalence of HCV (genotype 4) as about 14.7% of Egyptian populations are positive for HCV antibodies. Aim: To review recent data and patents concerning cytokine polymorphism that affect the likelihood of achieving SVR an Read More

Identification of putative biomarkers is a need of modern society today. Biomarker measures a biological or pathogenic process that can predict disease prognosis. It is important for monitoring drug safety, identification of individuals who are most likely to respond to specific treatments, stratification of presymptomatic patients and quantification of treatment benefits. The peripheral blood based identification of biomarke Read More

Though the first case of oral cancer related to HPV was reported in 1983, it was only in 2007, when WHO confirmed the role of human papilloma virus (HPV) in oropharyngeal cancer. Before this, the considered arch criminal for oropharyngeal cancer was primarily tobacco. In the last decade, there has been a sudden increase in oropharyngeal carcinoma in young individuals not being associated with tobacco and alcohol histor Read More

Oxidative stress is considered to be a prime cause of many diseases and is due to imbalance between the production of reactive oxygen species and the body's ability to detoxify these reactive intermediates. Current research on oxidative stress is to evaluate the reasons for the imbalance between oxygen species and antioxidants. Free radicals are generated within the living organisms and are involved in various cellular ac Read More

The calcium-sensing receptor is expressed almost ubiquitously throughout the human body, and is essential for calcium homeostasis and is involved in several disease pathomechanisms. Mainly in nephrology, therapeutic compounds acting on the receptor are already in use in clinical routine practice. The era of calcimimetic therapy, which commenced 10 years ago with the approval of the first-in-class compound cina Read More