Recent Patents on Biomarkers (Discontinued) - Volume 3, Issue 1, 2013

Involvement of extracellular ATP in inflammatory processes originated in the 1970s when Dahlquist and Diamant reported its histamine releasing action from mast cells. Later a specific ATP receptor was found on these cells, identified as the P2X7 receptor (P2X7R). From these early observations the P2X7R has become increasingly considered as an important regulator of inflammation. Since then, its key role in inflam Read More

Considerable evidence gained in the past decade has supported a better understanding and management of neurodegenerative diseases, in the face of the continuous increase of their prevalence in the world. Inflammation, mitochondrial dysfunction and oxidative stress are now recognized to be hallmarks of all neurological disorders. Along with therapies targeting these features, new therapeutic strategies are emerging, ba Read More

The toxicity of heavy metal varied on the absorption, concentration, and determination of the toxicant at its site of action. The end product of toxicant reacts with the endogenous target molecule like receptors, enzymes, DNA, protein, or lipid and seriously alters the biological micro environment, resulting structural and functional changes due to toxic damage. Heavy metals intoxication leads to increased lipid peroxid Read More

Delayed or improper diagnosis of bacterial infection can result in sepsis, serious, and often deadly or inflammatory response. Thus, there is a need for a simple assay that can detect low levels of bacteria, which are faster and sensitive in order to provide data for establish treatment decisions in a clinically relevant time frame. Advances in materials research and molecular biology play an important role in understand and develop Read More

Aspirin therapy is the cornerstone of therapy and is considered as the “gold standard” antiplatelet agent for primary and secondary prevention of cardiovascular events. Aspirin inhibits the COX-1 enzyme and therefore blocks platelet thromboxane A2 synthesis. Several recent studies have suggested that some patients may not get the full benefits of aspirin therapy. These findings raise the question that some patients may Read More

Hepatocellular Carcinoma remains a major fatal disease that is resistant to most cytotoxic therapeutics owed to the aberrant activation of signalling cascades. Recent patents reveal a new family of drugs that has been studied for molecularly targeting these cascades; multi-kinase inhibitors, are nowadays considered as novel therapeutic approaches. Therefore in this study, we aimed at investigating the impact of I Read More

Osteoarthritis (OA) is a multifactorial disease that affects millions of people around the world and it is the most common joint disease. The purpose of this study was to examine the kinetics of the expression of some lysosomal molecules and cellular process involved in the ethiopathogenesis of OA within two experimental models; also we reviewed recent patents on lysosomal proteins and discuss its possible value as early OA bi Read More