Recent Patents on Biomarkers (Discontinued) - Volume 2, Issue 1, 2012

Diabetes is a chronic condition that often requires life-long treatment. Hyperglycemia resulting from lack of diagnosis or neglect of the condition can result in devastating consequences. Early diagnosis and close monitoring of the condition may be the key to combat this disease. Saliva may have a role in diagnosing and monitoring diabetes. Recent studies and patents suggest that there is a potential of using this fluid in conju Read More

The aim of this article is to investigate patents and patent applications to the US Patent and Trademark Office, which are related to chronic kidney disease mineral and bone disorder (CKD-MBD). This term stands for a certain concept, which interprets bone disease of chronic kidney disease in a wider clinical context including coronary artery disease, extraosseous calcification and endocrine disorders. This concept which was intr Read More

A biomarker, or biological marker, is defined as a characteristic element that is objectively measured as an indicator of normal biological processes, pathogenic processes, or a pharmacological response to a therapeutic intervention. Oncology biomarkers are endogenous elements, present in tumor tissues or body fluids, whose amounts or modifications are indicative of tumor state, progression characteristics, and/or response Read More

SUMO-specific protease (SENP)1, a member of the SENPs family, has emerged as a potential target to reduce the development of various cancers. Importantly, SENP1 targets essential molecules involved in carcinogenesis. This article provides a review of current understanding of factors targeting and targeted by SENP1 in cancer. It also provides an overview of SENP1 and recently issued US patents that cover various stra Read More

The identification of a minor cellular subpopulation responsible for the initiation, maintenance and expansion of tumors (the cancer stem cells -CSCs-) meant a radical paradigm shift, but at the same time the selection of specific biomarkers may have extraordinary prognostic value. Recently, circulating epithelial cells (CTCs) have been identified in peripheral blood of solid tumor patients, demonstrating their prognosti Read More

This review informs on current literature on patents for biomarkers for asthma from 2009 to 2011. Variable airflow obstruction in asthma is generally triggered by gene-environment interactions that can lead to key symptoms of cough, shortness of breath, chest tightness, and wheezing. The episodic and variable degrees of airway hyperresponsiveness arise from a variety of inflammatory pathways that can make diagnos Read More

The aim of the study was to investigate bone metabolism after surgery through monitoring of bone turnover markers up to 1 year. Samples from 58 patients with diaphyseal fractures of the lower leg or tibia (group 1, n = 13), pertrochanteric femur fractures (group 2, n = 10), medial femoral neck fractures treated by cemented hip hemiarthroplasty (group 3, n = 13), soft tissue diseases (group 4, n = 12) and in patients who u Read More

The recent patents annotated in this section have been selected from various patent databases, and are relevant to the articles published in this journal issue. The patents are categorized in fast emerging patent biomarker applications e.g. discovery and validation in drug discovery, clinical development and molecular diagnostics, bioinformatics, preclinical biomarker discovery, personalized medicine, translational biomarker Read More