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- Volume 8, Issue 1, 2014
Recent Advances in DNA & Gene Sequences (Discontinued) - Volume 8, Issue 1, 2014
Volume 8, Issue 1, 2014
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Methods and Compositions for Amplification and Detection of microRNAs (miRNAs) and Noncoding RNAs (ncRNAs) Using the Signature Sequence Amplification Method (SSAM)
Authors: Stephen D. Ginsberg and Shaoli CheThe signature sequence amplification method (SSAM) described herein is an approach for amplifying noncoding RNA (ncRNA), microRNA (miRNA), and small polynucleotide sequences. A key point of the SSAM technology is the generation of signature sequences. The signature sequences include target sequences (miRNA, ncRNA, and/or any small polynucleotide sequence) flanked by two DNA fragments. Target sequences can be a Read More
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Conserved and Varied Dinucleotide Sequences in the Genomes of Three Aspergillus Species
More LessBoth guanine-cytosine content and nucleosome occupancy are higher in exons than in introns. In this study, the association between the frequencies of the dinucleotide sequences and the nucleosome occupancy of the exons and introns of the genes of Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae was studied. The frequency of the dinucleotide sequences AA (TT), AT, and TA in the introns Read More
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Discovery of Novel Antibiotic Resistance Genes Through Metagenomics
Authors: Marcos Lopez-Perez and Salvador MireteAntibiotic resistance (AR) represents a challenge for the treatment of infectious diseases. Traditionally, antibiotic resistance determinants have been retrieved from culturable bacteria which represent a minor fraction of the total microbial diversity found in natural environments such as soils. In this review, we summarize recent advances in the study of antibiotic resistance using two main culture-independent approaches Read More
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Analysis of Simple Sequence Repeats in Mammalian Cell Cycle Genes
Authors: Seema Trivedi, Christopher Wills and David MetzgarSimple sequence repeats (SSRs), or microsatellites are hyper-mutable and can lead to disorders. Here we explore SSR distribution in cell cycle-associated genes [grouped into: checkpoint; regulation; replication, repair, and recombination (RRR); and transition] in humans and orthologues of eight mammals. Among the gene groups studied, transition genes have the highest SSR density. Trinucleotide repeats are not abundant Read More
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Risk and Protective Effects of the Complexin-2 Gene and Gene-Environment Interactions in Schizophrenia
Authors: Roksana Zakharyan, Sofi Atshemyan and Anna BoyajyanSchizophrenia (SCZ) is a multifactorial chronic and disabling mental disease. The specific genetic variants contributing to disease complex phenotype are largely unknown. Growing amount of evidence suggested that aberrant synaptic connectivity contributes to SCZ pathogenesis. From this point of view, complexin-2, a presynaptic regulatory protein, represents here a special interest, since it has been recently shown tha Read More
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Effect of DNA Microenvironment on Photosensitized Reaction of Watersoluble Cationic Porphyrins
Authors: Kazutaka Hirakawa and Shuku NakajimaEndogenous and exogenous photosensitizers induce DNA damage, leading to carcinogenesis. Further, DNA is an important target biomacromolecule of photodynamic therapy (PDT) for cancer. Since the solar-induced DNA damage and PDT reaction occur in a complex biological environment, the interaction between biomolecule and photosensitizer is important. In this study, we examined the effect of a DNA micr Read More
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Recent Patents on Microbial Proteases for the Dairy Industry
This paper reviews the general characteristics of exo and endopeptidases of microbial origin currently used in the milk industry. It also includes recent patents developed either to potentiate the enzymatic activity or to improve the resulting milk derivatives. The main application of these proteases is in the cheese-making industry. Although this industry preferentially uses animal rennets, and in particular genetically engine Read More
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