Recent Patents on Nanomedicine - Current Issue

Hydrophobic drug entities are the major challenges for pharmaceutical scientists to deliver through oral route of administration due to limited drug solubility and bioavailability particularly emerged from combinatorial chemistry and computer aided drug design. Presently, self-emulsifying systems have been employed as the most common approach for delivery of numerous poor aqueous drugs. This unique strategy exploit Read More

Conventional drug delivery systems are related with drug, carrier and the route of administration based limitations as compared to novel drug delivery systems. Presently, nanolipid based carriers are the most appropriate delivery systems for poorly soluble drugs to improve the solubility of drugs and eventually oral bioavailability. Polymeric nanoparticles face some inherent drawback owing to its chemical properties such as l Read More

Lipid-Drug Conjugate (LDC) is an emerging field of nanotechnology which has potential applications in delivery of drugs and targeting them to specific site. Several molecules were supposed as promising and good therapeutic candidates during in vitro studies but they failed during in vivo studies showing the limited oral bioavailability as a major dilemma. LDC technological based approach played a vital role in augmenting Read More

Lipid-based drug delivery systems (LBDDS) are one of the most promising delivery systems for several drugs with poor solubility and bioavailability after administration through oral route and other routes of administration. A variety of drug candidates seek lipid based delivery owing to increased solubility and other benefits as discussed drug-wise in this chapter elsewhere. It is noteworthy that lipid based drug delivery is considere Read More

A variety of potent lipophilic drugs exhibits low oral bioavailability due to poor water solubility of drugs. These drugs are challenging for the formulation scientists with regard to solubility and bioavailability (BA). Extensive efforts are ongoing to enhance oral BA of these types of drugs to increase clinical efficacies. The most common approach is the use of highly developed lipid-based drug delivery systems. This is a strate Read More

Rheumatoid arthritis (RA) is an immune mediated joint based dreadful inflammatory disorder, which is characterized by joint destruction, swelling, pain and remission; it resulted to shorten lifespan and increased mortality rates. Current treatment approaches and their advancement have gained much attention in the prevention of RA and improvement in the many RA patients life. Despite their significant merits, still major Read More

IBD significantly affects the young population around the globe as the statistical reports worldwide showing the threatening growth in the IBD individuals and patients. The etiology and pathophysiology of the IBD are unclear and the causes of disease are also multifactorial. Identification, maintenance and management of the disease is a challenging aspect. This review focuses on various modern concepts revealed in the t Read More