Skip to content
2000
Volume 16, Issue 3
  • ISSN: 1872-2105
  • E-ISSN: 2212-4020

Abstract

Aim: The present study aims to develop and characterize simvastatin niosomal film for effective buccal delivery. Methods: Simvastatin niosomes were developed by film hydration technique followed by highpressure homogenization using chiller at 5°C. The simvastatin niosomes were characterized for various physicochemical parameters, and simvastatin plain and niosomal films were prepared using PEO as the base by solvent casting technique. Results: From the simvastatin niosomes suspension, the percentage assay was found in the range of 96% to 103%, particles size was found in the range of 112nm to 308nm, the zeta potential was found in the range of -9mV to -25.8mV, the %EE was found in the range of 28% to 91% and the in vitro permeation was found in the range of 43.41% to 98% respectively. The niosomal film shown superior results as compared to simvastatin plain film. The FTIR and DSC confirm the compatibility among the existed excipients. Conclusion: Niosomes alter the physicochemical properties of simvastatin by the buccal route. The prolonged permeation (96.12% up to 24hrs) of simvastatin was observed from niosomes film across the porcine buccal cavity due to the presence of CPE in the composition, which would be useful for effective buccal delivery.

Loading

Article metrics loading...

/content/journals/nanotec/10.2174/1872210515666210531112006
2022-09-01
2025-07-24
Loading full text...

Full text loading...

/content/journals/nanotec/10.2174/1872210515666210531112006
Loading

  • Article Type:
    Research Article
Keyword(s): buccal films; Chemical permeation enhancer; Cholesterol; Niosomes; Permeation; Span 60
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test