Letters in Organic Chemistry - Volume 15, Issue 2, 2018

Preparation and catalytic performance of nanosized copper particles supported on expanded corn starch (ECS) was investigated. The catalyst was characterized by inductively coupled plasma optical emission spectrometry (ICP-OES), X-ray powder diffraction (XRD), N2-sorption analysis, thermogravimetric analysis (TGA), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM). The copper Read More

Background: HIV-1 protease is a prime target for drug therapy due to its integral role in HIV viral replication. Several protease inhibitors such as lopinavir and tipranavir were shown to possess potent inhibitory activities against the HIV virus. Due to the high mutation rate of HIV, resistance remains a major problem in the treatment of this virus and design and synthesis of new protease inhibitors is an area of continued inter Read More

Background: Triazolothiadiazoles are molecules of great synthetic and pharmacological significance. They are associated with significant antimicrobial, antifungal, antibacterial, antihelmintic and anti-inflammatory activities. Method: The condensation of 5-alkyl-4-amino-3-mercapto-4H-1,2,4-triazoles with 3-aryl-1- phenylpyrazole-4-carboxylic acids was carried out in the presence of phosphoryl chloride and the resulting Read More

Chalcone oximes are important molecules in organic chemistry. Extant literature contains several methods for conversion of chalcones to their oxime forms but rapid and efficient new methods need to be developed. In this study; we have investigated a new, microwave assisted synthetic method for conversion of chalcones to their oxime forms. For this purpose, a series of known chalcones were synthesized and converte Read More

Background: Sulfonamide derivatives belong to the most important structural classes of drug molecules. This functional group constitutes the largest class of antibacterial agents. Antibacterial agents with a sulfonamide structure, e.g. sulfadiazine have been therapeutically used for many decades. Approved drugs with a sulfonamide structure have found widespread utility in a number of pharmacology and medicine applic Read More

Background: Functional organic dyes with donor-π-conjugation-acceptor (D-π-A) molecular structure and electron transfer in the excited state have attracted much attention because of their potential applications in optical, electronics, magnets materials, dye sensitized solar cells (DSSCs), organic light emitting diodes (OLED), sensors, solid state lasers and photovoltaic cells and thin film transistors. Methods: An efficient and Read More

Background: Cancer is a major health problem worldwide and the major cause of human mortality in the world. The identification of novel structures for effective treatment of cancer is still a major challenge to medicinal chemists. Over the time, important milestones have been achieved in the development of various cancer static drugs for antitumor chemotherapy. Chemotherapy is still highly inadequate, and th Read More

The Knoevenagel reaction is one of the most useful methods for the synthesis of α,β- unsaturated nitriles. We disclose an efficient protocol for the Knoevenagel reaction of aldehydes with malononitrile catalyzed by 1-alkyl-1,2,4-triazolium salts to afford the corresponding products in excellent yields. The important feature of this reaction is the catalyst; 1-alkyl-1,2,4-triazolium salts are recycled and reused. Furthermore, the rea Read More

Background: Technical mixture of styrenated phenols including mono-, di-, and tristyrenated phenol, has been commonly applied for industrial materials such as rubber or plastic stabilizer, antioxidant, and nonionic surfactant, etc. Among these styrenated phenols, di-styrenated phenol should be most effective as rubber and plastic stabilizers. Although a number of catalysts for the synthesis of styrenated phenols have b Read More

Background: Carbohydrate fatty acid esters are found in important biological molecules such as bile acid 1-O-acyl galacto and bacterial glycolipids. The synthesis of glycomimetics of those biomolecules is required to study their structure-activity relationship. Method: In this work a series of carbohydrate fatty acid esters were regioselectively prepared mainly via protection and deprotection and tin-mediated strategies of par Read More

As a part of our continuous efforts in synthesizing potent anti-cancer natural product cephalostatin 1 and its analogues using a symmetrical bits-steroidal diketone, progress in the chemoselective distinction of the two parts is reported. The first strategy involves the highly chemoselective reductive opening of the spiroketal moiety (ring-F) of nonsymmetrical diol precursor. Thus, the protected 12β,12´α-diol underwent a che Read More