Ultrasound-promoted Regioselective Synthesis of 2-aryl-quinazolinones Using Citric Acid as a Natural and Efficient Media and Catalyst

A three-component reaction under ultrasound irradiation and with a catalytic amount of citric acid was presented for the synthesis of a series of 2-aryl-quinazolin-4(1H)-ones with excellent efficiency and short reaction time. This one-pot reaction with 2-aminobenzonitrile, ammonium hydroxide or glycine and benzaldehydes is a clean and safe route for the environment at room temperature. Mild reaction conditions, green environment, excellent performance, simple method and reduction of environmental consequences are the advantages of the present method. The structures of many synthesized 2-aryl-quinazolin-4(1H)-one compounds were confirmed by ¹H, ¹³C NMR and FTIR spectral data and elemental analysis.