Convenient Synthetic Approaches for Novel Impurities of Propisochlor Herbicide

A facile and convenient synthesis of two new and one known impurities of Propisochlor, 2-chloro-N-(2-chloroethanoyl)-N-(2-ethyl-6-methylphenyl)-ethanamide, 2,2-dichloro-N-(2- ethyl-6-methyl-phenyl)-N-(isopropxymethyl)-ethanamide and 2-chloro-N-(2-ethyl-6-methylphenyl)- N-methylethanamide have been developed from the readily available 2-ethyl-6-methylaniline precursor. All the synthesized impurities are characterized using ¹H, ¹³C NMR and mass spectra for their structural elucidation.