The Synthesis of Amides from Benzoic Acids and Dicarbodiimides Under Catalyst-Free Conditions

Amides are a critical class of widely distributed heterocycles in nature. The preparation of amides from benzoic acids and dicarbodiimides under catalyst-free conditions was reported. Various products were obtained in good to high yields. The model reaction could be scaled up to the gramscale level. A reaction mechanism was proposed based on control experiments and relevant literatures.