Preparation of Tetrasubstituted Bis(3-indolyl)methanes from Indoles and Acetophenes Using 1,3-dibromo-5,5-dimehtylhydantoin as an Efficient Catalyst

A new process that could efficiently prepare tetrasubstituted bis(3-indolyl)methanes from various indoles and acetophenones with 1,3-Dibromo-5,5-dimehtylhydantoin(DBDMH) as a catalyst was reported. The effects of catalysts, solvents, and reaction temperature were investigated. Under the optimal condition, most of the tetrasubstituted bis(3-indolyl)methanes were obtained in 90–99% yields.