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2000
Volume 16, Issue 1
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bisflavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

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/content/journals/loc/10.2174/1570178615666180621094529
2019-01-01
2025-07-08
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