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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation
- Source: Letters in Organic Chemistry, Volume 16, Issue 1, Jan 2019, p. 30 - 33
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- 01 Jan 2019
Abstract
A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.
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