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2000
Volume 15, Issue 4
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

In this work, two new prolinamides with isosteviol skeleton were synthesized and used as chiral catalysts for the asymmetric aldol reaction. Solvent effects, catalyst loading, substrate scope and the influence of water on the reaction were investigated. With only 5 mol % loading, the synthesized catalysts showed excellent activity (up to 98% yield) and good stereoselectivity (up to 87:13 dr, 90% ee) for the direct aldol reaction of cyclohexanone and substituted benzaldehydes at room temperature.

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/content/journals/loc/10.2174/1570178615666171226163338
2018-04-01
2025-07-06
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/content/journals/loc/10.2174/1570178615666171226163338
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  • Article Type:
    Research Article
Keyword(s): Aldol reaction; asymmetric catalysis; isosteviol; organocatalyst; prolinamide; synthesis
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