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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Removal of the Chiral Inductor from Phenylglycinol-derived Tricyclic Lactams. Unexpected Generation of Chiral trans-Hydrochromene Lactones
- Source: Letters in Organic Chemistry, Volume 15, Issue 5, May 2018, p. 335 - 339
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- 01 May 2018
Abstract
In the search for synthetic routes for the preparation of cis- and trans- decahydroquinolin-2- ones, a procedure for the generation of enantiopure trans-hydrochromene lactones, by treatment of (R)- phenylglycinol-derived oxazoloquinolone lactams with Na/liq. NH3 followed by acidification, has been developed.
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