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2000
Volume 15, Issue 7
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

Background: In the present study, fourteen new 1,2,4-triazole Schiff bases and eight new 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines incorporating a pyrimidine ring were synthesized and evaluated for their antibacterial activity. Methods: 1,2,4-Triazole Schiff bases were prepared from the condensation of 4-amino-3-mercapto-5- (2-thiomethylpyrimidyl)-1,2,4-triazole with a series of arylaldehydes in the presence of (+)-tartaric acid as catalyst. On the other hand, the reaction of 4-amino-3-mercapto-5-(2-thiomethylpyrimidyl)-1,2,4- triazole with substituted phenacyl bromides afforded the corresponding 1,2,4-triazolo[3,4-b][1,3,4]- thiadiazines. Results: The structures of 1,2,4-triazole Schiff bases and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines were characterized by IR, NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activities using 96-well microbroth dilution assay. Conclusion: Schiff base with p-hydroxylphenyl substituent and triazolothiadiazine containing 4- flurophenyl ring displayed moderate antibacterial activity against Pseudomonas aeruginosa at MIC 62.5 μg/ml.

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/content/journals/loc/10.2174/1570178614666171129160503
2018-07-01
2025-07-14
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/content/journals/loc/10.2174/1570178614666171129160503
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  • Article Type:
    Research Article
Keyword(s): 1,2,4-Triazole; antibacterial; condensation; pyrimidine; Schiff base; triazolothiadiazine
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