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2000
Volume 15, Issue 5
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

An efficient procedure for the direct arylation of pyrrolidine with phenols and naphtols is reported. Upon reaction with catalytic amounts of a binuclear copper(II)-7-azaindole complex under an atmosphere of oxygen, pyrrolidine is smoothly oxidized to the corresponding imine which can be trapped by a series of phenols and naphtols in fair to good yields. This copper-catalyzed direct oxidative arylation of pyrrolidine offers an efficient entry to α-aryl-pyrrolidines in a single step and without the need for protecting or directing groups.

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/content/journals/loc/10.2174/1570178614666171120164418
2018-05-01
2025-07-13
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