Green and Facile Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via a Click Reaction of α-Bromo Ketones, [bmim]N3 and Terminal Acetylenes

An efficient and green one pot method is reported for regioselective synthesis of 1,4-disubstituted 1,2,3- triazoles. In this method, β.-ketoazides are generated via in situ reaction between α-bromo ketones and 1-butyl-3- methylimidazolium azide [bmim]N3 in aqueous ethanol and reacted with terminal acetylenes using Cu-CuSO4 at room temperature to afford 1,4-disubstituted 1,2,3-triazoles.