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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions
- Source: Letters in Organic Chemistry, Volume 10, Issue 2, Feb 2013, p. 121 - 125
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- 01 Feb 2013
Abstract
A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)2O without any additive at room temperature. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields.
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