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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines
- Source: Letters in Organic Chemistry, Volume 9, Issue 7, Sep 2012, p. 497 - 502
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- 01 Sep 2012
Abstract
The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.
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