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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Practical Corey-Chaykovsky Epoxidation: Scope and Limitation
- Source: Letters in Organic Chemistry, Volume 8, Issue 7, Sep 2011, p. 509 - 514
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- 01 Sep 2011
Abstract
Corey-Chaykovsky epoxidation is one of the versatile methods for synthesis of structurally diverse oxiranes. The extension of simplified Corey-Chaykovsky epoxidation has been investigated. Ketones and aromatic aldehydes were epoxidized in satisfactory to excellent yields with trimethylsulfonium iodide as an ylide precursor and crushed potassium hydroxide as a base in tertiary butanol. The scope and limitation of the simplified procedure were examined. The results revealed that the procedure is applicable to the epoxidation of ketones and aromatic aldehydes.
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