A Procedure for Facile Synthesis of Nucleosides Using N, O-Bistrimethylsilylacetamide in the Presence of Natural Phosphate Coated with Potassium Iodide

Several α-D/L-arabino and β-D/L- xylonucleosides were synthesized in good yields under mild conditions by N-glycosylation of 1-O-acetyl D/L- arabino, and xylofuranose, with silylated nucleobases (uracil, thymine and 6- azauracil) in acetonitrile using natural phosphate (NP) coated with potassium iodide in BSA as catalyst.