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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Chiral Phosphoric Acid Catalyzed Diastereo- and Enantioselective 1,4- Conjugate Addition of β-Ketoesters to Nitroolefins
- Source: Letters in Organic Chemistry, Volume 7, Issue 3, Apr 2010, p. 219 - 225
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- 01 Apr 2010
Abstract
Chiral phosphoric acid as organocatalyst for the diastereo- and enantioselectivity 1,4-conjugate addition of a variety of β-ketoesters to nitroolefins was firstly developed, providing the corresponding adducts in high yield (up to 97%) with moderate diastereoselectivities (up to 2.6:1 dr) and enantioselectivities (up to 58% ee).
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