Full text loading...
- ISSN: 1570-1786
- E-ISSN: 1875-6255
-
Improved Condensation of 2-pyridyllithium Intermediates with Aldehydes: Application for the Synthesis of 2-(polyhydroxyalkyl)pyridines
- Source: Letters in Organic Chemistry, Volume 6, Issue 1, Jan 2009, p. 50 - 56
-
- 01 Jan 2009
Abstract
The scope and the limitations of 3-chloro-2-pyridinyl lithium condensation to aldehydes were envisioned depending on metallation conditions or condensation time and temperatures. The procedure was applied to various aromatic, aliphatic or functionalized aldehydes to afford a new and efficient access to 2-(polyhydroxyalkyl)pyridines.
© Bentham Science Publishers