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2000
Volume 5, Issue 7
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A new two-step, one-pot alternative protocol for preparation of 1H-pyrazole-5-amines from 3-oxoalkanenitriles utilizing readily available acetylhydrazine has been developed. Typical by-products formed in traditional reactions of 3- oxoalkanenitriles with hydrazine are not formed when the present method is used, thus facilitating purification on a large scale. The method was used to prepare a medicinally important heterocycle on a kilogram scale.

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/content/journals/loc/10.2174/157017808785982266
2008-10-01
2025-07-10
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/content/journals/loc/10.2174/157017808785982266
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  • Article Type:
    Research Article
Keyword(s): 3-oxoalkanenitriles; acetylhydrazine; aminopyrazoles; kilogram scale; process chemistry
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