Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines having Electron-Withdrawing Substituents

Hideto Miyabe; Akira Matsumura; Kazumasa Yoshida; Masashige Yamauchi; Yoshiji Takemoto

doi:10.2174/1570178043488464

ISSN: 1570-1786
E-ISSN: 1875-6255

Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines having Electron-Withdrawing Substituents
Authors: Hideto Miyabe¹, Akira Matsumura², Kazumasa Yoshida³, Masashige Yamauchi⁴ and Yoshiji Takemoto⁵
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¹ Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. ² Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. ³ Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. ⁴ Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. ⁵ Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Source: Letters in Organic Chemistry, Volume 1, Issue 2, Apr 2004, p. 119 - 121
DOI: https://doi.org/10.2174/1570178043488464
- Available online: 01 Apr 2004

Abstract

As a new direct functionalization of guanidines, the N-allylic substitution of guanidines was studied. The nitrogen atom of guanidine derivatives having two Nelectron- withdrawing substituents acted as a reactive nucleophile in the allylic substitution.

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2004-04-01

2025-06-19

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Article Type: Review Article

Keyword(s): allylation; allylic substitution; catalytic reaction; guanidine; iridium; palladium

Palladium or Iridium-Catalyzed Allylic Substitution of Guanidines having Electron-Withdrawing Substituents

Abstract

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