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2000
Volume 1, Issue 2
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

Two routes are examined to achieve the synthesis of a glutarimide possessing a quaternary asymmetric centre with good stereocontrol. It appears that the first one, involving enantioselective Michael addition of cyano-4-(3,4-dichlorophenyl)butanoate on allyl acrylate is the most interesting in terms of cleanness of reactions and stereocontrol. The best system involves a quinidine derived catalyst at - 40°C with potassium hydroxide as a base and gave a medium ee (60%).

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/content/journals/loc/10.2174/1570178043488365
2004-04-01
2025-07-03
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