3,4,6-Trisubstituted-2-Pyrone Synthesis via the Nucleophilic Addition of 2- Alkyl Meldrum's Acid to Alkynyl Ketone

Iwao Hachiya; Hitoshi Shibuya; Kazuma Hanai; Makoto Shimizu

doi:10.2174/1570178043400505

ISSN: 1570-1786
E-ISSN: 1875-6255

3,4,6-Trisubstituted-2-Pyrone Synthesis via the Nucleophilic Addition of 2- Alkyl Meldrum's Acid to Alkynyl Ketone
Authors: Iwao Hachiya¹, Hitoshi Shibuya², Kazuma Hanai³ and Makoto Shimizu⁴
View Affiliations Hide Affiliations

¹ Department of Chemistry for Materials, Mie University, Tsu, Mie 514-8507, Japan. ² Department of Chemistry for Materials, Mie University, Tsu, Mie 514-8507, Japan. ³ Department of Chemistry for Materials, Mie University, Tsu, Mie 514-8507, Japan. ⁴ Department of Chemistry for Materials, Mie University, Tsu, Mie 514-8507, Japan.
Source: Letters in Organic Chemistry, Volume 1, Issue 4, Oct 2004, p. 349 - 352
DOI: https://doi.org/10.2174/1570178043400505
- Available online: 01 Oct 2004

Abstract

3,4,6-Trisubstituted-2-pyrone synthesis via the nucleophilic addition of 2-alkyl Meldrum's acid to alkynyl ketone has been developed. The reaction of 2-alkyl Meldrum's acid with alkynyl ketones provided 3,4,6-trisubstituted-2-pyrones in good yields. The reaction of dialkynyl ketones gave 6-alkynyl-2-pyrones.

Article metrics loading...

/content/journals/loc/10.2174/1570178043400505

2004-10-01

2025-06-18

From This Site

/content/journals/loc/10.2174/1570178043400505

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/loc/10.2174/1570178043400505

Article Type: Review Article

Keyword(s): 2-pyrone; alkynyl ketone; dialkynyl ketone; meldrums acid

3,4,6-Trisubstituted-2-Pyrone Synthesis via the Nucleophilic Addition of 2- Alkyl Meldrum's Acid to Alkynyl Ketone

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Vilsmeier-Haack Cyclisation as a Facile Synthetic Route to Thieno [2,3- b] Quinolines (Part I)

Efficient Synthesis of 4-Arylmethylene-3-methylisoxazol-5(4H)-one Derivatives Catalyzed by Malic Acid

Wonderful Natural Drugs with Surprising Nutritional Values, Rheum Species, Gifts of the Nature

Novel Derivatives Based on Zerumbone Scaffold as Potential Anticancer Inhibitors

A Review on the Syntheses and Applications of the 5H-chromeno[2,3- b]pyridines

Fe Doped Ga2O3 Nanomaterial Catalysed Green and Efficient One Pot Three Component Synthesis of Tetrahydrobenzo[b]pyran

Sulfonated Ethylenediamine Functionalized Magnetic Nanoparticles as a Highly Efficient Heterogeneous Nanocatalyst for the Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

K2CO3/TBAB, a Composite of Inorganic and Organic Salts, a Novel and Powerful Media for Regioselective Michael Addition of Dihydropyrimidinones to Acrylic Esters Under and Without Solvent Conditions

Decomposition Kinetics of 1,1-Dihydroperoxycyclohexane in Some Organic Solvents

In Silico Screening of Some Anti-Cancer Drugs Against the Main Protease of COVID-19 Using Molecular Docking