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2000
Volume 22, Issue 4
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

In this work, 2,3,4-tri-O-acetyl-D-glucurono-6,1-lactone has been prepared from glucuronic acid in two steps by converting it into glucuronic anhydride. In the presence of a catalytic amount of Ce(OTf) (10 examples) in ethyl acetate, the glucuronic anhydride provided 6.1-lactone in good to excellent yields. This lactone was used to prepare the novel glycoconjugates of peptidic fragments of arenastatin A, a sponge cytotoxic depsipeptide, and its analogues.

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2025-07-15

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Ce(OTf)3-Catalyzed Synthesis of Glucopyranurono-6,1-Lactone: A Key Intermediate for Obtaining Glycoconjugates of Peptidic Fragments of Arenastatin A
Lett. Org. Chem. 22, 317 (2025); https://doi.org/10.2174/0115701786325021240817182955
/content/journals/loc/10.2174/0115701786325021240817182955
/content/journals/loc/10.2174/0115701786325021240817182955
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  • Article Type:     Research Article
Keyword(s): anticancer; arenastatin A; catalysis; cytotoxicity; depsipeptide; Glucuronic acid; glycoconjugate

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