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Volume 22, Issue 3
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

The amide group is one of the most ubiquitous chemical motifs in the pharmaceutical field. An efficient continuous flow synthesis of amides was achieved by coupling acids with amines using 2-bromo-1-ethylpyridinium tetrafluoroborate (BEP) in the bio-derived “green” solvent γ-valerolactone (GVL). The reaction proceeded under mild reaction conditions (ambient temperature, 1 min) with simple filtration without the need for extensive purification, allowing a safe and on-demand generation of procainamide and VH032-Boc with a productivity of 0.44 g day-1 and 0.99 g day-1. The finding of our work aligned with green chemistry principles should result in its adoption by the chemistry community.

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2024-08-22
2025-04-24

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/content/journals/loc/10.2174/0115701786313379240815113722
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Continuous Flow Synthesis of Amides in Bio-Derived Solvent GVL
Letters in Organic Chemistry 22, 194 (2025); https://doi.org/10.2174/0115701786313379240815113722
/content/journals/loc/10.2174/0115701786313379240815113722
/content/journals/loc/10.2174/0115701786313379240815113722
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  • Article Type:     Research Article
Keyword(s): 2-bromo-1-ethylpyridinium tetrafluoroborate; amide condensation; bio-derived solvent; continuous flow chemistry; green solvents; γ-Valerolactone

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