Base and Backbone Modified Oligonucleotides and their Application As Antisense Agent

The synthesis, some basic physicochemical properties and the application as an antisense molecule of modified oligonucleotides will be discussed in this article. The oligonucleotides covered in this section are base and/or backbone modified oligonucleotides. The influence of the modifications on the thermal stability of the duplexes consisting of the modified oligonucleotides is discussed. At the same time, the influence of the modifications on the nucleaseresistant property of the modified oligonucleotides is also discussed. The antisense activity of some modified oligonucleotides is included with available data. The relevant references are presented at the end of this article.