Skip to content
2000
Volume 7, Issue 2
  • ISSN: 1871-5265
  • E-ISSN: 2212-3989

Abstract

The identification of new antibacterial targets is urgently needed to address multidrug resistant and latent tuberculosis infection. Sulfur metabolic pathways are essential for survival and the expression of virulence in many pathogenic bacteria, including Mycobacterium tuberculosis. In addition, microbial sulfur metabolic pathways are largely absent in humans and therefore, represent unique targets for therapeutic intervention. In this review, we summarize our current understanding of the enzymes associated with the production of sulfated and reduced sulfur-containing metabolites in Mycobacteria. Small molecule inhibitors of these catalysts represent valuable chemical tools that can be used to investigate the role of sulfur metabolism throughout the Mycobacterial lifecycle and may also represent new leads for drug development. In this light, we also summarize recent progress in the development of inhibitors of sulfur metabolism enzymes.

Loading

Article metrics loading...

/content/journals/iddt/10.2174/187152607781001772
2007-06-01
2025-05-01
Loading full text...

Full text loading...

/content/journals/iddt/10.2174/187152607781001772
Loading

  • Article Type:
    Research Article
Keyword(s): drug design; enzymes; inhibitors; mycobacteria; sulfation; sulfur metabolism; thiols; Tuberculosis
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test