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Volume 25, Issue 1
  • ISSN: 1871-5265
  • E-ISSN: 2212-3989

Abstract

Background

Antimicrobial resistance exhibited by bacteria against the majority of antibiotics has resulted in research on alternative methods of treatment. Aloe vera has a strong tradition as a medical plant with a wide range of therapeutic uses.

Objective

The objective of this study is to determine the antibacterial activity of gel and crude ethanol leaf extract of Aloe vera against and isolated from wound infections.

Methods

It is a cross-sectional study conducted over a period of 7 months. Antibacterial effect of the ethanol leaf extract and gel was determined by the punch well method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the ethanol leaf extract were determined by macro broth dilution technique.

Results

Aloe vera ethanol leaf extract induced a mean zone size of 13.0 ± 6.0 mm and 16.7 ± 8.4 mm, respectively, for and Enterobacterales by Punch Well method (≤0.002). Whereas Aloe vera gel failed to induce any zone of inhibition for all the isolates <0.001. Mean MIC of Aloe vera leaf extract against 74 was 94 ± 41.23 mg/ml and against 73 Enterobacterales, it was 45.6 ± 20 mg/ml < 0.001. Mean MBC of Aloe vera leaf extract against 74 isolates was 188 ± 82.46 mg/ml and against 73 Enterobacterales was 91.18±40 mg/ml < 0.001.

Conclusion

Aloe vera ethanol leaf extract showed a good antibacterial effect against the different strains of bacteria causing wound infection. The present article shows the possibility of future use of natural products for the treatment of wound infections.

© 2025 Bentham Science Publishers
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2024-06-28
2025-01-11

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References

  1. MohammedA. SeidM.E. GebrecherkosT. TirunehM. MogesF. Bacterial isolates and their antimicrobial susceptibility patterns of wound infections among inpatients and outpatients attending the university of Gondar Referral Hospital, Northwest Ethiopia.Int. J. Microbiol.2017201711010.1155/2017/8953829 28386280
     [Google Scholar]
  2. RoopashreeS. PrathabA.G. T S. Bacteriological profile and antibiotic susceptibility patterns of wound infections in a tertiary care hospital in South India.Indian J. Microbiol. Res.202181768510.18231/j.ijmr.2021.016
     [Google Scholar]
  3. SaleemA. NaureenI. NaeemM. MuradH.S. MaqsoodS. TasleemG. Aloe vera gel effect on skin and pharmacological properties. Schol.Int J Anat Physiol2022511810.36348/sijap.2022.v05i01.001
     [Google Scholar]
  4. AmaliaN. FajrinaA. EriadiA. Antimicrobial activity test of aloe vera plant extract: A review article.Sci. Int. 2020326721727
     [Google Scholar]
  5. DanishP. AliQ. HafeezM.M. MalikA. Antifungal and antibacterial activity of aloe vera plant extract.Biolog Clin Sci Res J20202020e00410.54112/bcsrj.v2020i1.4
     [Google Scholar]
  6. HekmatpouD. MehrabiF. RahzaniK. AminiyanA. The effect of Aloe vera clinical trials on prevention and healing of skin wound: A systematic review.Iran. J. Med. Sci.201944119 30666070
     [Google Scholar]
  7. PrasadS.D. GodaP.C. ReddyK.S. KumarC.S. HemadriM. Ranga ReddyD.S. Evaluation of antimicrobial efficacy of neem and Aloe vera leaf extracts in comparison with 3% sodium hypochlorite and 2% chlorhexidine against E. faecalis and C. albicans.J NTR Univ Health Sci20165210411010.4103/2277‑8632.185436
     [Google Scholar]
  8. LiuC. CuiY. PiF. ChengY. GuoY. QianH. Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from Aloe vera: A review.Molecules2019248155410.3390/molecules24081554 31010204
     [Google Scholar]
  9. AdziteyF. AgbolosuA.A. UdokaU.J. Antibacterial Effect of Aloe Vera Gel Extract on Escherichia coli and Salmonella enterica Isolated from the Gastrointestinal Tract of Guinea Fowls.World Vet. J.20199316617310.36380/scil.2019.wvj21
     [Google Scholar]
  10. ArbabS. UllahH. WeiweiW. Comparative study of antimicrobial action of aloe vera and antibiotics against different bacterial isolates from skin infection.Vet. Med. Sci.2021752061206710.1002/vms3.488 33949142
     [Google Scholar]
  11. CrichtonP.B. Enterobacteriaceae: Escherichia, klebsiella, proteus and other genera.Mackie & McCartney Practical Medical Microbiology. ColleeJ.G. FraserG.A. MarmionB.P. SimmonsA. New YorkChurchill Livingstone, Elsevier publishers2012361404
     [Google Scholar]
  12. GoudarziM. FazeliM. AzadM. SeyedjavadiS.S. MousaviR. Aloe vera gel: Effective therapeutic agent against multidrug resistant Pseudomonas aeruginosa isolates recovered from burn wound infections.Chemother. Res. Pract.201520151510.1155/2015/639806 26266047
     [Google Scholar]
  13. NortjieE. BasitereM. MoyoD. NyamukambaP. Extraction Methods, Quantitative and Qualitative Phytochemical Screening of Medicinal Plants for Antimicrobial Textiles: A Review.Plants20221115201110.3390/plants11152011 35956489
     [Google Scholar]
  14. HayatK.M. KumarT. AhmadN. JanS.A. SajjadW. FaisalS. In vitro antimicrobial activity of Aloe vera L. extracts against pathogenic bacteria and fungi.Mycopath2016142127
     [Google Scholar]
  15. WaithakaPN EliudMG BensonMG KazunguR Z Antimicrobial properties of Aloe vera, Aloe volkensii and Aloe secundiflora from Egerton University.Acta Sci Microbiol2018150610
     [Google Scholar]
  16. RudrangshuC. DushyantS. DimriA.G. PanditaA. ChaudharyS. AggarwalM.L. Comparative study of antimicrobial activity of Aloe vera gel and antibiotics against isolates.World J. Pharm. Pharm. Sci.20154410541058
     [Google Scholar]
  17. ArseneM.M.J. ViktorovnaP.I. SergeiG.V. Phytochemical analysis, antibacterial and antibiofilm activities of Aloe vera aqueous extract against selected resistant gram-negative bacteria involved in urinary tract infections.Fermentation202281162610.3390/fermentation8110626
     [Google Scholar]
  18. CataldiV. BartolomeoD.S. CampliD.E. NostroA. CelliniL. Di GiulioM. In vitro activity of Aloe vera inner gel against microorganisms grown in planktonic and sessile phases.Int. J. Immunopathol. Pharmacol.201528459560210.1177/0394632015600594 26526205
     [Google Scholar]
  19. JainS. RathodN. NagiR. Antibacterial effect of Aloe vera gel against oral pathogens: An in-vitro study.J. Clin. Diagn. Res.20161011ZC41ZC4410.7860/JCDR/2016/21450.8890 28050502
     [Google Scholar]
  20. DarshanD. PagiN. JasaniH. PatelP. Antimicrobial Activity and Phytochemical Screening of Aloe vera (Aloe barbadensis Miller).Int. J. Curr. Microbiol. Appl. Sci.201762152216210.20546/ijcmas.2017.603.246
     [Google Scholar]
  21. AzzahraS. ParisaN. Antibacterial efficacy of Aloe vera sap against Staphylococcus aureus and Escherichia coli.J Biomed Transl Res2019322937
     [Google Scholar]
  22. YahyaR. Al-RajhiA.M.H. AlzaidS.Z. Molecular docking and efficacy of Aloe vera gel based on chitosan nanoparticles against Helicobacter pylori and its antioxidant and anti-inflammatory activities.Polymers20221415299410.3390/polym14152994 35893958
     [Google Scholar]
  23. JosephA.M.M. JorelleA.B. SarraS. ViktorovnaP.I. DavaresA.K. IngridN.K. Short review on the potential alternatives to antibiotics in the era of antibiotic resistance.J. Appl. Pharm. Sci.2022122940
     [Google Scholar]
/content/journals/iddt/10.2174/0118715265301138240605071106
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Antibacterial effect of Aloe Vera on Bacteria Isolated from Cases of Wound Infection
Infect. Disord. Drug Targets 25, e280624231439 (2025); https://doi.org/10.2174/0118715265301138240605071106
/content/journals/iddt/10.2174/0118715265301138240605071106
/content/journals/iddt/10.2174/0118715265301138240605071106
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  • Article Type:     Research Article
Keyword(s): antibacterial agents; Escherichia coli; ethanol; Klebsiella spp.; Plant extract; Staphylococcus aureus

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