Skip to content
2000
Volume 14, Issue 3
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873

Abstract

Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e.g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant therapeutic strategies with strategies of weight loss. Among antioxidants, melatonin holds a special place, on the one hand for its antioxidant and anti-inflammatory properties, and on the other hand for its role as a metabolic regulator. As melatonin modulates several processes involved in obesity and its related metabolic alterations, it could have a therapeutic interest in the treatment of obesity.

Loading

Article metrics loading...

/content/journals/emiddt/10.2174/1871530314666140604151452
2014-09-01
2025-05-23
Loading full text...

Full text loading...

/content/journals/emiddt/10.2174/1871530314666140604151452
Loading

  • Article Type:
    Research Article
Keyword(s): Antioxidant; insulin resistance; melatonin; metabolic syndrome; obesity
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test