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image of The Molecular Determinants of Erythrocyte Removal Impact the Development of Metabolic Dysfunction-Associated Steatohepatitis
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Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is a major cause of a worldwide clinical and financial burden. Despite the tremendous efforts for untangling the molecular mechanisms, there is still a need for defining specific therapeutic targets. In this editorial, the author will focus on the role of erythrocyte death and hepatic erythrophagocytosis in MASH. Evidence indicates that erythrolysis prior to erythrophagocytosis protects against the development of MASH, while phagocytosis of intact erythrocytes culminates in hepatic inflammation. Furthermore, understanding the balance between erythrolysis and intact erythrocyte engulfment could lead to the development of new strategies for the treatment of MASH.

© 2024 The Author(s). Published by Bentham Science Publishers
© 2024 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode.
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2024-12-09
2025-01-18

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References

  1. Younossi Z.M. Koenig A.B. Abdelatif D. Fazel Y. Henry L. Wymer M. Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016 64 1 73 84 10.1002/hep.28431 26707365
    [Google Scholar]
  2. Younossi Z.M. Marchesini G. Pinto-Cortez H. Petta S. Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: implications for liver transplantation. Transplantation 2019 103 1 22 27 10.1097/TP.0000000000002484 30335697
    [Google Scholar]
  3. Younossi Z.M. Tampi R.P. Racila A. Qiu Y. Burns L. Younossi I. Nader F. Economic and clinical burden of nonalcoholic steatohepatitis in patients with type 2 diabetes in the U.S. Diabetes Care 2020 43 2 283 289 10.2337/dc19‑1113 31658974
    [Google Scholar]
  4. Hateley C. Olona A. Halliday L. Edin M.L. Ko J.H. Forlano R. Terra X. Lih F.B. Beltrán-Debón R. Manousou P. Purkayastha S. Moorthy K. Thursz M.R. Zhang G. Goldin R.D. Zeldin D.C. Petretto E. Behmoaras J. Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity. EBioMedicine 2024 103 105127 10.1016/j.ebiom.2024.105127 38677183
    [Google Scholar]
  5. Pirola C.J. Salatino A. Fernández Gianotti T. Castaño G.O. Garaycoechea M. Sookoian S. Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease. EBioMedicine 2024 101 104996 10.1016/j.ebiom.2024.104996 38320344
    [Google Scholar]
  6. Noureddin M. Sanyal A.J. Pathogenesis of NASH: The impact of multiple pathways. Curr. Hepatol. Rep. 2018 17 4 350 360 10.1007/s11901‑018‑0425‑7 31380156
    [Google Scholar]
  7. Papadopoulos C. Tentes I. Papazoglou D. Anagnostopoulos K. Lysophospholipid metabolism and signalling in non-alcoholic fatty liver disease. Folia Med. (Plovdiv) 2022 64 1 7 12 10.3897/folmed.64.e59297 35851901
    [Google Scholar]
  8. Papadopoulos C. Tentes I. Anagnostopoulos K. Lipotoxicity disrupts erythrocyte function: A perspective. Cardiovasc. Hematol. Disord. Drug Targets 2021 21 2 91 94 10.2174/1871529X21666210719125728 34825642
    [Google Scholar]
  9. Papadopoulos C. Erythrocyte glucotoxicity results in vascular inflammation. Endocr. Metab. Immune Disord. Drug Targets 2022 22 9 901 903 10.2174/1871530322666220430013334 35507805
    [Google Scholar]
  10. Theurl I. Hilgendorf I. Nairz M. Tymoszuk P. Haschka D. Asshoff M. He S. Gerhardt L.M.S. Holderried T.A.W. Seifert M. Sopper S. Fenn A.M. Anzai A. Rattik S. McAlpine C. Theurl M. Wieghofer P. Iwamoto Y. Weber G.F. Harder N.K. Chousterman B.G. Arvedson T.L. McKee M. Wang F. Lutz O.M.D. Rezoagli E. Babitt J.L. Berra L. Prinz M. Nahrendorf M. Weiss G. Weissleder R. Lin H.Y. Swirski F.K. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat. Med. 2016 22 8 945 951 10.1038/nm.4146 27428900
    [Google Scholar]
  11. Qi J. Kim J.W. Zhou Z. Lim C.W. Kim B. Ferroptosis affects the progression of nonalcoholic steatohepatitis via the modulation of lipid peroxidation–mediated cell death in mice. Am. J. Pathol. 2020 190 1 68 81 10.1016/j.ajpath.2019.09.011 31610178
    [Google Scholar]
  12. Otogawa K. Kinoshita K. Fujii H. Sakabe M. Shiga R. Nakatani K. Ikeda K. Nakajima Y. Ikura Y. Ueda M. Arakawa T. Hato F. Kawada N. Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am. J. Pathol. 2007 170 3 967 980 10.2353/ajpath.2007.060441 17322381
    [Google Scholar]
  13. Park J.B. Ko K. Baek Y.H. Kwon W.Y. Suh S. Han S.H. Kim Y.H. Kim H.Y. Yoo Y.H. Pharmacological prevention of ectopic erythrophagocytosis by cilostazol mitigates ferroptosis in NASH. Int. J. Mol. Sci. 2023 24 16 12862 10.3390/ijms241612862 37629045
    [Google Scholar]
  14. Puylaert P. Roth L. Van Praet M. Pintelon I. Dumitrascu C. van Nuijs A. Klejborowska G. Guns P.J. Berghe T.V. Augustyns K. De Meyer G.R.Y. Martinet W. Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques. Angiogenesis 2023 26 4 505 522 10.1007/s10456‑023‑09877‑6 37120604
    [Google Scholar]
  15. Pfefferlé M. Ingoglia G. Schaer C.A. Yalamanoglu A. Buzzi R. Dubach I.L. Tan G. López-Cano E.Y. Schulthess N. Hansen K. Humar R. Schaer D.J. Vallelian F. Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes. J. Clin. Invest. 2020 130 10 5576 5590 10.1172/JCI137282 32663195
    [Google Scholar]
  16. Papadopoulos C. Spourita E. Mimidis K. Kolios G. Tentes L. Anagnostopoulos K. Nonalcoholic fatty liver disease patients exhibit reduced CD47 and increased sphingosine, cholesterol, and monocyte chemoattractant protein-1 levels in the erythrocyte membranes. Metab. Syndr. Relat. Disord. 2022 20 7 377 383 10.1089/met.2022.0006 35532955
    [Google Scholar]
  17. Papadopoulos C. Mimidis K. Tentes I. Tente T. Anagnostopoulos K. Validation and application of a protocol for the extraction and quantitative analysis of sphingomyelin in erythrocyte membranes of patients with non-alcoholic fatty liver disease. J. Planar Chromatogr. Mod. TLC 2021 34 5 411 418 10.1007/s00764‑021‑00127‑3
    [Google Scholar]
  18. Choi Y.K. Kim Y.M. Beneficial and detrimental roles of heme oxygenase-1 in the neurovascular system. Int. J. Mol. Sci. 2022 23 13 7041 10.3390/ijms23137041 35806040
    [Google Scholar]
  19. Santarino I.B. Vieira O.V. Maturation of phagosomes containing different erythrophagocytic particles in primary macrophages. FEBS Open Bio 2017 7 9 1281 1290 10.1002/2211‑5463.12262 28904858
    [Google Scholar]
  20. Nguyen J.A. Yates R.M. Better together: Current insights into phagosome-lysosome fusion. Front. Immunol. 2021 12 636078 10.3389/fimmu.2021.636078 33717183
    [Google Scholar]
  21. Catala A. Metabolic reprogramming of mouse bone marrow derived macrophages following erythrophagocytosis. Front Physiol. 2020 11 396 10.3389/fphys.2020.00396
    [Google Scholar]
  22. Zhang K.R. Jankowski C.S.R. Marshall R. Nair R. Más Gómez N. Alnemri A. Liu Y. Erler E. Ferrante J. Song Y. Bell B.A. Baumann B.H. Sterling J. Anderson B. Foshe S. Roof J. Fazelinia H. Spruce L.A. Chuang J.Z. Sung C.H. Dhingra A. Boesze-Battaglia K. Chavali V.R.M. Rabinowitz J.D. Mitchell C.H. Dunaief J.L. Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells. Dis. Model. Mech. 2023 16 7 dmm050066 10.1242/dmm.050066 37401371
    [Google Scholar]
  23. Rayego-Mateos S. Morgado-Pascual J.L. García-Caballero C. Lazaro I. Sala-Vila A. Opazo-Rios L. Mas-Fontao S. Egido J. Ruiz-Ortega M. Moreno J.A. Intravascular hemolysis triggers NAFLD characterized by a deregulation of lipid metabolism and lipophagy blockade. J. Pathol. 2023 261 2 169 183 10.1002/path.6161 37555366
    [Google Scholar]
/content/journals/emiddt/10.2174/0118715303362972241121062515
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  • Article Type:     Review Article
Keywords: efferocytosis ; immunometabolism ; Ferroptosis ; MASH ; erythrophagocytosis ; erythrocytes

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