Skip to content
2000
image of Ketogenic Diet and Endocrine and Metabolic Diseases: A Bibliometric Study and Visualization Analysis

Abstract

Background

The ketogenic diet, known for its high-fat, low-carbohydrate composition, has been extensively studied in endocrine and metabolic diseases. This study carried out bibliometric analysis to examine the research trends in this field over the past 20 years, aiming to provide insights for future studies.

Methods

We searched the Web of Science Core Collection for all relevant papers. VOSviewer was used for network visualization, the bibliometrix package of R software (version 4.3.0) was utilized for data analysis, and CiteSpace was employed for mapping and trend analysis.

Results

This study encompassed 508 relevant articles spanning from 2003 to 2023, authored by 2827 researchers from 887 institutions across 57 countries/regions. The total number of publications increased from 3 in 2003 to 508 in 2023, showing a steady growth trend. The United States emerged as the predominant contributor in this field, followed by Italy and China. Notably, SAJOUX I consistently exhibited high activity in this field, according to the analysis, with an h-index of 13. The journal has consistently made substantial contributions to this field, accounting for 19% of all publications.-The keywords “obesity,” “ketogenic diet,” and “weight loss” appeared most frequently, with “obesity” occurring 163 times.

Conclusion

This study used a bibliometric method to analyze the impact of the ketogenic diet on the endocrine metabolic system. The research identifies recent frontiers and trending directions, providing valuable references for scholars in this field.

© 2024 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
Loading

Article metrics loading...

/content/journals/emiddt/10.2174/0118715303317289240820114329
2024-10-28
2024-11-30
Loading full text...

Full text loading...

/deliver/fulltext/emiddt/10.2174/0118715303317289240820114329/BMS-EMIDDT-2024-123.html?itemId=/content/journals/emiddt/10.2174/0118715303317289240820114329&mimeType=html&fmt=ahah

References

  1. Mezhnina V. Ebeigbe O.P. Velingkaar N. Poe A. Sandlers Y. Kondratov R.V. Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network. Proc. Natl. Acad. Sci. USA 2022 119 40 e2205755119 10.1073/pnas.2205755119 36161962
    [Google Scholar]
  2. Newman J.C. Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol. Metab. 2014 25 1 42 52 10.1016/j.tem.2013.09.002 24140022
    [Google Scholar]
  3. Lee T.I. Trang N.N. Lee T.W. Higa S. Kao Y.H. Chen Y.C. Chen Y.J. Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy. Int. J. Mol. Sci. 2023 24 22 16142 10.3390/ijms242216142 38003332
    [Google Scholar]
  4. Ünalp A. Ünay B. Arhan E. Editorial: The use of ketogenic diet therapy in the era of individualized therapy. Front. Nutr. 2023 10 1272170 10.3389/fnut.2023.1272170 37794968
    [Google Scholar]
  5. Kossoff E.H. More fat and fewer seizures: dietary therapies for epilepsy. Lancet Neurol. 2004 3 7 415 420 10.1016/S1474‑4422(04)00807‑5 15207798
    [Google Scholar]
  6. Hartman A.L. Vining E.P.G. Clinical aspects of the ketogenic diet. Epilepsia 2007 48 1 31 42 10.1111/j.1528‑1167.2007.00914.x 17241206
    [Google Scholar]
  7. Kossoff E.H. Zupec-Kania B.A. Auvin S. Ballaban-Gil K.R. Christina Bergqvist A.G. Blackford R. Buchhalter J.R. Caraballo R.H. Cross J.H. Dahlin M.G. Donner E.J. Guzel O. Jehle R.S. Klepper J. Kang H.C. Lambrechts D.A. Liu Y.M.C. Nathan J.K. Nordli D.R. Jr Pfeifer H.H. Rho J.M. Scheffer I.E. Sharma S. Stafstrom C.E. Thiele E.A. Turner Z. Vaccarezza M.M. van der Louw E.J.T.M. Veggiotti P. Wheless J.W. Wirrell E.C. Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group. Epilepsia Open 2018 3 2 175 192 10.1002/epi4.12225 29881797
    [Google Scholar]
  8. Gazerani P. Diet and migraine: what is proven? Curr. Opin. Neurol. 2023 36 6 615 621 10.1097/WCO.0000000000001204 37865855
    [Google Scholar]
  9. Schoeler N.E. Marston L. Lyons L. Halsall S. Jain R. Titre-Johnson S. Balogun M. Heales S.J.R. Eaton S. Orford M. Neal E. Reilly C. Eltze C. Stephen E. Mallick A.A. O’Callaghan F. Agrawal S. Parker A. Kirkpatrick M. Brunklaus A. McLellan A. McCullagh H. Samanta R. Kneen R. Tan H.J. Devlin A. Prasad M. Rattihalli R. Basu H. Desurkar A. Williams R. Fallon P. Nazareth I. Freemantle N. Cross J.H. Classic ketogenic diet versus further antiseizure medicine in infants with drug-resistant epilepsy (KIWE): a UK, multicentre, open-label, randomised clinical trial. Lancet Neurol. 2023 22 12 1113 1124 10.1016/S1474‑4422(23)00370‑8 37977712
    [Google Scholar]
  10. Kawon K. Rugiel M. Setkowicz Z. Matusiak K. Kubala-Kukus A. Stabrawa I. Szary K. Rauk Z. Chwiej J. Ketogenic diet influence on the elemental homeostasis of internal organs is gender dependent. Sci. Rep. 2023 13 1 18448 10.1038/s41598‑023‑45611‑4 37891248
    [Google Scholar]
  11. Nadjarzadeh A. Ghadiri-Anari A. Ramezani-Jolfaie N. Mohammadi M. Salehi-Abargouei A. Namayande S.M. Mozaffari-Khosravi H. Hosseini-Marnani E. Effect of hypocaloric high-protein, low-carbohydrate diet supplemented with fennel on androgenic and anthropometric indices in overweight and obese women with polycystic ovary syndrome: A randomized placebo-controlled trial. Complement. Ther. Med. 2021 56 102633 10.1016/j.ctim.2020.102633 33271298
    [Google Scholar]
  12. Coppedè F. Franzago M. Giardina E. Nigro C.L. Matullo G. Moltrasio C. Nacmias B. Pileggi S. Sirchia S.M. Stoccoro A. Storlazzi C.T. Stuppia L. Tricarico R. Merla G. A perspective on diet, epigenetics and complex diseases: where is the field headed next? Epigenomics 2022 14 20 1281 1304 10.2217/epi‑2022‑0239 36325816
    [Google Scholar]
  13. Westman E.C. Yancy W.S. Jr Mavropoulos J.C. Marquart M. McDuffie J.R. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr. Metab 2008 5 1 36 10.1186/1743‑7075‑5‑36 19099589
    [Google Scholar]
  14. Badman M.K. Kennedy A.R. Adams A.C. Pissios P. Maratos-Flier E. A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. Am. J. Physiol. Endocrinol. Metab. 2009 297 5 E1197 E1204 10.1152/ajpendo.00357.2009 19738035
    [Google Scholar]
  15. Ai S. Li Y. Zheng H. Wang Z. Liu W. Tao J. Li Y. Wang Y. Global research trends and hot spots on autophagy and kidney diseases: a bibliometric analysis from 2000 to 2022. Front. Pharmacol. 2023 14 1275792 10.3389/fphar.2023.1275792 38099142
    [Google Scholar]
  16. Hirsch J.E. An index to quantify an individual’s scientific research output. Proc. Natl. Acad. Sci. USA 2005 102 46 16569 16572 10.1073/pnas.0507655102 16275915
    [Google Scholar]
  17. Abbas A.M. Bounds and inequalities relating h-index, g-index, e-index and generalized impact factor: an improvement over existing models. PLoS One 2012 7 4 e33699 10.1371/journal.pone.0033699 22496760
    [Google Scholar]
  18. Musbahi A. Rao C.B. Immanuel A. A Bibliometric Analysis of Robotic Surgery From 2001 to 2021. World J. Surg. 2022 46 6 1314 1324 10.1007/s00268‑022‑06492‑2 35258666
    [Google Scholar]
  19. He H. D. Liu C. Chen M. L. Guo X. Z. Li X. Y. Xiang Z. X. Liao F. Dong W. G. Effect of Dietary Patterns on Inflammatory Bowel Disease: A Machine Learning Bibliometric and Visualization Analysis. Nutrients 2023 15 15 24 10.3390/nu15153442
    [Google Scholar]
  20. Chen C. Searching for intellectual turning points: progressive knowledge domain visualization. Proc. Natl. Acad. Sci. U. S. A. 2004 101 Suppl 1 5303 5310 10.1073/pnas.0307513100
    [Google Scholar]
  21. Barrea L. Verde L. Schiavo L. Sarno G. Camajani E. Iannelli A. Caprio M. Pilone V. Colao A. Muscogiuri G. Very Low-Calorie Ketogenic Diet (VLCKD) as Pre-Operative First-Line Dietary Therapy in Patients with Obesity Who Are Candidates for Bariatric Surgery. Nutrients 2023 15 8 1907 10.3390/nu15081907 37111126
    [Google Scholar]
  22. Paoli A. Mancin L. Giacona M.C. Bianco A. Caprio M. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J. Transl. Med. 2020 18 1 104 10.1186/s12967‑020‑02277‑0 32103756
    [Google Scholar]
  23. Rinaldi R. De Nucci S. Castellana F. Di Chito M. Giannuzzi V. Shahini E. Zupo R. Lampignano L. Piazzolla G. Triggiani V. Cozzolongo R. Giannelli G. De Pergola G. The Effects of Eight Weeks’ Very Low-Calorie Ketogenic Diet (VLCKD) on Liver Health in Subjects Affected by Overweight and Obesity. Nutrients 2023 15 4 825 10.3390/nu15040825 36839183
    [Google Scholar]
  24. Goldberg E.L. Asher J.L. Molony R.D. Shaw A.C. Zeiss C.J. Wang C. Morozova-Roche L.A. Herzog R.I. Iwasaki A. Dixit V.D. β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep. 2017 18 9 2077 2087 10.1016/j.celrep.2017.02.004 28249154
    [Google Scholar]
  25. Guarnotta V. Amodei R. Di Gaudio F. Giordano C. Nutritional Intervention in Cushing’s Disease: The Ketogenic Diet’s Effects on Metabolic Comorbidities and Adrenal Steroids. Nutrients 2023 15 21 4647 10.3390/nu15214647 37960300
    [Google Scholar]
  26. Yancy W.S. Jr Olsen M.K. Guyton J.R. Bakst R.P. Westman E.C. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann. Intern. Med. 2004 140 10 769 777 10.7326/0003‑4819‑140‑10‑200405180‑00006 15148063
    [Google Scholar]
  27. Balooch Hasankhani M. Mirzaei H. Karamoozian A. Global trend analysis of diabetes mellitus incidence, mortality, and mortality-to-incidence ratio from 1990 to 2019. Sci. Rep. 2023 13 1 21908 10.1038/s41598‑023‑49249‑0 38081899
    [Google Scholar]
  28. Al-Khalifa A. Mathew T.C. Al-Zaid N.S. Mathew E. Dashti H.M. Therapeutic role of low-carbohydrate ketogenic diet in diabetes. Nutrition 2009 25 11-12 1177 1185 10.1016/j.nut.2009.04.004 19818281
    [Google Scholar]
  29. Willi S.M. Martin K. Datko F.M. Brant B.P. Treatment of type 2 diabetes in childhood using a very-low-calorie diet. Diabetes Care 2004 27 2 348 353 10.2337/diacare.27.2.348 14747212
    [Google Scholar]
  30. Yuan X. Wang J. Yang S. Gao M. Cao L. Li X. Hong D. Tian S. Sun C. Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis. Nutr. Diabetes 2020 10 1 38 10.1038/s41387‑020‑00142‑z 33257645
    [Google Scholar]
  31. Lommi J. Kupari M. Koskinen P. Näveri H. Leinonen H. Pulkki K. Härkönen M. Blood ketone bodies in congestive heart failure. J. Am. Coll. Cardiol. 1996 28 3 665 672 10.1016/0735‑1097(96)00214‑8 8772754
    [Google Scholar]
  32. Inagaki N. Goda M. Yokota S. Maruyama N. Iijima H. Safety and efficacy of canagliflozin in Japanese patients with type 2 diabetes mellitus: post hoc subgroup analyses according to body mass index in a 52-week open-label study. Expert Opin. Pharmacother. 2015 16 11 1577 1591 10.1517/14656566.2015.1055250 26104600
    [Google Scholar]
  33. Nedoboy P.E. Cohen M. Farnham M.M.J. Slow but Steady—The Responsiveness of Sympathoadrenal System to a Hypoglycemic Challenge in Ketogenic Diet-Fed Rats. Nutrients 2021 13 8 2627 10.3390/nu13082627 34444787
    [Google Scholar]
  34. Hill J.O. Peters J.C. Catenacci V.A. Wyatt H.R. International strategies to address obesity. Obes. Rev. 2008 9 s1 41 47 10.1111/j.1467‑789X.2007.00437.x 18307698
    [Google Scholar]
  35. Shetty P. Schmidhuber J. Introductory lecture the epidemiology and determinants of obesity in developed and developing countries. Int. J. Vitam. Nutr. Res. 2006 76 4 157 162 10.1024/0300‑9831.76.4.157 17243077
    [Google Scholar]
  36. Gaspa G. Naciu A.M. Di Rosa C. Lattanzi G. Beato I. Micheli V. Turriziani C. Khazrai Y.M. Cesareo R. Short- and long-term effects of very low- and low-calorie ketogenic diets on metabolism and cardiometabolic risk factors: a narrative review. Minerva Endocrinol. 2023 48 3 318 333 10.23736/S2724‑6507.22.03922‑7 36285748
    [Google Scholar]
  37. Cignarelli A. Santi D. Genchi V.A. Conte E. Giordano F. Di Leo S. Natalicchio A. Laviola L. Giorgino F. Perrini S. Very low‐calorie ketogenic diet rapidly augments testosterone levels in non‐diabetic obese subjects. Andrology 2023 11 2 234 244 10.1111/andr.13357 36459060
    [Google Scholar]
  38. Ivan C.R. Messina A. Cibelli G. Messina G. Polito R. Losavio F. Torre E.L. Monda V. Monda M. Quiete S. Casula E. Napoli N. Defeudis G. Italian Ketogenic Mediterranean Diet in Overweight and Obese Patients with Prediabetes or Type 2 Diabetes. Nutrients 2022 14 20 4361 10.3390/nu14204361 36297044
    [Google Scholar]
  39. Deledda A. Palmas V. Heidrich V. Fosci M. Lombardo M. Cambarau G. Lai A. Melis M. Loi E. Loviselli A. Manzin A. Velluzzi F. Dynamics of Gut Microbiota and Clinical Variables after Ketogenic and Mediterranean Diets in Drug-Naïve Patients with Type 2 Diabetes Mellitus and Obesity. Metabolites 2022 12 11 1092 10.3390/metabo12111092 36355175
    [Google Scholar]
  40. Barrea L. Verde L. Santangeli P. Lucà S. Docimo A. Savastano S. Colao A. Muscogiuri G. Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach. J. Transl. Med. 2023 21 1 128 10.1186/s12967‑023‑03956‑4 36800966
    [Google Scholar]
  41. Barrea L. Muscogiuri G. Aprano S. Vetrani C. de Alteriis G. Varcamonti L. Verde L. Colao A. Savastano S. Phase angle as an easy diagnostic tool for the nutritionist in the evaluation of inflammatory changes during the active stage of a very low-calorie ketogenic diet. Int. J. Obes. 2022 46 9 1591 1597 10.1038/s41366‑022‑01152‑w 35614205
    [Google Scholar]
  42. Garruti G. Baj J. Cignarelli A. Perrini S. Giorgino F. Hepatokines, bile acids and ketone bodies are novel Hormones regulating energy homeostasis. Front. Endocrinol 2023 14 1154561 10.3389/fendo.2023.1154561 37274345
    [Google Scholar]
  43. Paoli A. Cerullo G. Investigating the Link between Ketogenic Diet, NAFLD, Mitochondria, and Oxidative Stress: A Narrative Review. Antioxidants 2023 12 5 1065 10.3390/antiox12051065 37237931
    [Google Scholar]
  44. King A.N. Notaro N.M. The ketogenic diet maintains insulin sensitivity and inhibits lipid accumulation in the liver. J. Physiol. 2022 600 21 4543 4545 10.1113/JP283784 36161655
    [Google Scholar]
  45. Watanabe M. Tozzi R. Risi R. Tuccinardi D. Mariani S. Basciani S. Spera G. Lubrano C. Gnessi L. Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature. Obes. Rev. 2020 21 8 e13024 10.1111/obr.13024 32207237
    [Google Scholar]
  46. Cooper I.D. Sanchez-Pizarro C. Norwitz N.G. Feldman D. Kyriakidou Y. Edwards K. Petagine L. Elliot B.T. Soto-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model. Front. Endocrinol 2023 14 1326768 10.3389/fendo.2023.1326768 38189051
    [Google Scholar]
  47. Magagnini M.C. Condorelli R.A. Cimino L. Cannarella R. Aversa A. Calogero A.E. La Vignera S. Does the Ketogenic Diet Improve the Quality of Ovarian Function in Obese Women? Nutrients 2022 14 19 4147 10.3390/nu14194147 36235799
    [Google Scholar]
  48. Muscogiuri G. Palomba S. Laganà A. Orio F. Current Insights Into Inositol Isoforms, Mediterranean and Ketogenic Diets for Polycystic Ovary Syndrome: From Bench to Bedside. Curr. Pharm. Des. 2016 22 36 5554 5557 10.2174/1381612822666160720160634 27510483
    [Google Scholar]
  49. Pandurevic S. Mancini I. Mitselman D. Magagnoli M. Teglia R. Fazzeri R. Dionese P. Cecchetti C. Caprio M. Moretti C. Sicinska J. Agostini A. Gazineo D. Godino L. Sajoux I. Fanelli F. Meriggiola C.M. Pagotto U. Gambineri A. Efficacy of very low-calorie ketogenic diet with the Pronokal® method in obese women with polycystic ovary syndrome: a 16-week randomized controlled trial. Endocr. Connect. 2023 12 7 e220536 10.1530/EC‑22‑0536 37018117
    [Google Scholar]
  50. Calcaterra V. Cena H. Sottotetti F. Hruby C. Madini N. Zelaschi N. Zuccotti G. Low-Calorie Ketogenic Diet: Potential Application in the Treatment of Polycystic Ovary Syndrome in Adolescents. Nutrients 2023 15 16 3582 10.3390/nu15163582 37630772
    [Google Scholar]
  51. Gohari S. Ghobadi S. Jafari A. Ahangar H. Gohari S. Mahjani M. The effect of dietary approaches to stop hypertension and ketogenic diets intervention on serum uric acid concentration: a systematic review and meta-analysis of randomized controlled trials. Sci. Rep. 2023 13 1 10492 10.1038/s41598‑023‑37672‑2 37380733
    [Google Scholar]
  52. Gambardella J. Jankauskas S.S. Kansakar U. Varzideh F. Avvisato R. Prevete N. Sidoli S. Mone P. Wang X. Lombardi A. Santulli G. Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling. JACC Basic Transl. Sci. 2023 8 9 1123 1137 10.1016/j.jacbts.2023.03.014 37791311
    [Google Scholar]
  53. Ni H. Biagini G. Upadhya D. Capuano A. Editorial: Endocrine Modulators of Neurological Processes: Potential Treatment Targets of Pediatric Neurological Diseases. Front. Endocrinol 2021 12 655290 10.3389/fendo.2021.655290 33679621
    [Google Scholar]
  54. Shalabi H. Alotaibi A. Alqahtani A. Alattas H. Alghamdi Z. Ketogenic Diets: Side Effects, Attitude, and Quality of Life. Cureus 2021 13 12 e20390 10.7759/cureus.20390 35036220
    [Google Scholar]
  55. Abbasi J. Interest in the Ketogenic Diet Grows for Weight Loss and Type 2 Diabetes. JAMA 2018 319 3 215 217 10.1001/jama.2017.20639 29340675
    [Google Scholar]
  56. Keene D.L. A systematic review of the use of the ketogenic diet in childhood epilepsy. Pediatr. Neurol. 2006 35 1 1 5 10.1016/j.pediatrneurol.2006.01.005 16814077
    [Google Scholar]
  57. Kanikarla-Marie P. Jain S.K. Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes. Free Radic. Biol. Med. 2016 95 268 277 10.1016/j.freeradbiomed.2016.03.020 27036365
    [Google Scholar]
/content/journals/emiddt/10.2174/0118715303317289240820114329
Loading
/content/journals/emiddt/10.2174/0118715303317289240820114329
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test