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Volume 25, Issue 5
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873

Abstract

Introduction

Adrenal tuberculosis remains the main cause of primary adrenal insufficiency (PAI) in tuberculosis (TB)-prevalent regions. This case report details the presentation of PAI due to adrenal TB, where the etiological diagnosis involves Abdominal Computed Tomography (CT).

Case Report

A 37-year-old Peruvian woman with a history of TB contact displayed symptoms of adrenal insufficiency. PAI diagnosis was established, and CT imaging unveiled bilateral adrenal enlargement with calcifications. Treatment with prednisone and anti-TB therapy led to symptomatic improvement. Unfortunately, she succumbed to pneumonia after ten months of follow-up.

Discussion

Adrenal TB must be considered in endemic regions and in the presence of a TB history. CT serves as a valuable diagnostic tool, particularly in settings with limited resources, revealing adrenal enlargement and calcifications.

Conclusion

In patients with PAI, epidemiological history of TB, and when a rapid biopsy is not feasible, CT proves to be a valuable diagnostic method.

© 2025 Bentham Science Publishers
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2024-07-23
2025-05-29

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References

  1. HahnerS. RossR.J. ArltW. BancosI. Burger-StrittS. TorpyD.J. HusebyeE.S. QuinklerM. Adrenal insufficiency.Nat. Rev. Dis. Primers2021711910.1038/s41572‑021‑00252‑7 33707469
     [Google Scholar]
  2. BornsteinS.R. AllolioB. ArltW. BarthelA. Don-WauchopeA. HammerG.D. HusebyeE.S. MerkeD.P. MuradM.H. StratakisC.A. TorpyD.J. Diagnosis and treatment of primary adrenal insufficiency: An endocrine society clinical practice guideline.J. Clin. Endocrinol. Metab.2016101236438910.1210/jc.2015‑1710 26760044
     [Google Scholar]
  3. MoscaA.M. BarbosaM. AraújoR. SantosM.J. Addison’s disease: A diagnosis easy to overlook.Cureus2021132e1336410.7759/cureus.13364 33747659
     [Google Scholar]
  4. HusebyeE.S. PearceS.H. KroneN.P. KämpeO. Adrenal insufficiency.Lancet20213971027461362910.1016/S0140‑6736(21)00136‑7 33484633
     [Google Scholar]
  5. BarthelA BenkerG BerensK DiederichS ManfrasB GruberM An update on addison’s disease.Exp. Clin. Endocrinol. Diabetes,201912702/0316517510.1055/a‑0804‑2715
     [Google Scholar]
  6. KumarR. WassifW.S. Adrenal insufficiency.J. Clin. Pathol.202275743544210.1136/jclinpath‑2021‑207895 35534201
     [Google Scholar]
  7. FerreiraS. Freitas-SilvaM. The importance of computed tomography findings in detecting tuberculous addison’s disease.Eur. J. Case Rep. Intern. Med.201721410.12890/2017_000622 30755954
     [Google Scholar]
  8. VinnardC. BlumbergE.A. Endocrine and metabolic aspects of tuberculosis.Microbiol. Spectr.2017513110.1128/9781555819866.ch30
     [Google Scholar]
  9. Eslava OrozcoD.F. Tovar CortésH. Fuentes TrespalaciosR. Tuberculous adrenalitis: About an update.Rev. Repert. Med. Cir.20223113341
     [Google Scholar]
  10. PangY. AnJ. ShuW. HuoF. ChuN. GaoM. QinS. HuangH. ChenX. XuS. Epidemiology of extrapulmonary tuberculosis among inpatients, China, 2008–2017.Emerg. Infect. Dis.201925345746410.3201/eid2503.180572 30789144
     [Google Scholar]
  11. GuptaS. AnsariMAM. GuptaAK. ChaudharyP. BansalLK. Current approach for diagnosis and treatment of adrenal tuberculosis-our experience and review of literature.Surg. J. 202281e92e9710.1055/s‑0042‑1743523
     [Google Scholar]
  12. HuangH. GaoL. LiY. TanW. WuH. YuanY. LiuC. Adrenal tuberculosis: A case report and literature review.Urol. Int.2023107880781310.1159/000529711 37075720
     [Google Scholar]
  13. Dávila-ArandaB. Córdova-ValenzuelaV. Carrillo-SanabriaG. Meza-LeguaF. Tinoco-SolórzanoA. Dávila-ArandaB. Tomographic diagnosis of primary adrenal tuberculosis in Addison’s disease at altitude. Case report.Rev Fac Med Humana.2020204727730
     [Google Scholar]
  14. CarsoteM. NistorC. Addison’s disease: Diagnosis and management strategies.Int. J. Gen. Med.2023162187221010.2147/IJGM.S390793 37287503
     [Google Scholar]
  15. IsemanM.D. Tuberculosis therapy: Past, present and future.Eur. Respir. J.20022036Suppl. 3687S94s10.1183/09031936.02.00309102 12168751
     [Google Scholar]
  16. ChoykeP.L. Commentary on “Computed tomography in the diagnosis of adrenal disease” and “Nonfunctioning adrenal masses: Incidental discovery on computed tomography”.AJR Am. J. Roentgenol.2009192356857010.2214/AJR.08.1718 19234249
     [Google Scholar]
  17. TranN.Q. PhanC.C. DoanT.T.P. TranT.V. Bilateral adrenal masses due to tuberculosis: How to diagnose without extra-adrenal tuberculosis.Endocrinol. Diabetes Metab. Case Rep.2021219310.1530/EDM‑21‑0093
     [Google Scholar]
  18. HuangY.C. TangY.L. ZhangX.M. ZengN.L. LiR. ChenT.W. Evaluation of primary adrenal insufficiency secondary to tuberculous adrenalitis with computed tomography and magnetic resonance imaging: Current status.World J. Radiol.201571033634210.4329/wjr.v7.i10.336 26516430
     [Google Scholar]
  19. BacarizoP. Rosario ChecaM. Suárez LlanosP. HernándezL. Jara AlbarránA. Radiological evolution in the follow-up of tuberculous adrenalitis.Endocrinol. Nutr.200653851051410.1016/S1575‑0922(06)71140‑8
     [Google Scholar]
  20. YangZ.G. GuoY.K. LiY. MinP.Q. YuJ.Q. MaE.S. Differentiation between tuberculosis and primary tumors in the adrenal gland: evaluation with contrast-enhanced CT.Eur. Radiol.20061692031203610.1007/s00330‑005‑0096‑y 16435135
     [Google Scholar]
  21. KelestimurF. The endocrinology of adrenal tuberculosis: The effects of tuberculosis on the hypothalamo-pituitary-adrenal axis and adrenocortical function.J. Endocrinol. Invest.200427438038610.1007/BF03351067 15233561
     [Google Scholar]
  22. GoldmanS.M. CoelhoR.D. Freire FilhoE.O. AbdalaN. SzejnfeldD. FariaJ. JudiceP.L.P. FranciscoV.V. KenneyP.J. SzejnfeldJ. Imaging procedures in adrenal pathology.Arq. Bras. Endocrinol. Metabol200448559261110.1590/S0004‑27302004000500004 15761529
     [Google Scholar]
  23. ZedingZ. LiuL. WangC. TianQ. ZhangJ. ZenY. ZhangN. ShenJ. NaA. M.; BaSang, P.; Lv, X.; Yang, S.; Meng, S.; Yang, L. A retrospective analysis of 25 cases of Addison’s disease caused by adrenal tuberculosis in Tibet and review of related literature.J. Clin. Tuberc. Other Mycobact. Dis.20233110035810.1016/j.jctube.2023.100358 37102162
     [Google Scholar]
  24. KimJ.H. ChoiM.H. Embryonic development and adult regeneration of the adrenal gland.Endocrinol. Metab. 202035476577310.3803/EnM.2020.403 33397037
     [Google Scholar]
/content/journals/emiddt/10.2174/0118715303305534240709115115
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Diagnostic Role of Tomography in Addison's Disease due to Adrenal Tuberculosis: A Case Report
Endocr Metab Immune Disord Drug Targets 25, 421 (2025); https://doi.org/10.2174/0118715303305534240709115115
/content/journals/emiddt/10.2174/0118715303305534240709115115
/content/journals/emiddt/10.2174/0118715303305534240709115115
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  • Article Type:     Case Report
Keyword(s): Addison’s disease; adrenal gland neoplasms; anti-TB therapy; diagnostic imaging; endocrine tuberculosis; X-ray computed tomography

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