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Volume 23, Issue 2
  • ISSN: 1570-1611
  • E-ISSN: 1875-6212
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Abstract

Background

Contrast-induced Acute Kidney Injury (CI-AKI) frequently occurs as a complication following percutaneous coronary intervention (PCI), making the identification of high-risk patients challenging. While the systemic immune inflammation index (SII) might aid in predicting CI-AKI, the current evidence remains insufficient.

Methods

We conducted a systematic literature search using PubMed, Web of Science, Embase, and the Cochrane Library, with a cut-off date of 3/20/2024. We included observational studies that examined the predictive value of SII for the risk of CI-AKI.

Results

This meta-analysis encompassed 8 studies with a combined total of 6301 participants. Results showed pooled sensitivity and specificity of 0.73 (95% CI 0.69-0.76) and 0.68 (95% CI 0.57-0.77), respectively. The sROC curve analysis indicated an AUC of 0.74 (95% CI 0.70-0.78). The risk of publication bias was low (p = 0.18).

Conclusion

The results of this study suggest that SII has a relatively high sensitivity and could function as a biomarker for the prediction of CI-AKI risk in people receiving PCI treatment.

© 2025 Bentham Science Publishers
© 2025 The Author(s). Published by Bentham Science Publisher. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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/content/journals/cvp/10.2174/0115701611328810241028112700
2024-11-05
2025-04-13

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/content/journals/cvp/10.2174/0115701611328810241028112700
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The Systemic Immune Inflammation Index as a Novel Predictive Biomarker for Contrast-Induced Acute Kidney Injury Risk Following Percutaneous Coronary Intervention: A Meta-Analysis of Cohort Studies
Curr. Vasc. Pharmacol. 23, 136 (2025); https://doi.org/10.2174/0115701611328810241028112700
/content/journals/cvp/10.2174/0115701611328810241028112700
/content/journals/cvp/10.2174/0115701611328810241028112700
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  • Article Type:     Research Article
Keyword(s): contrast-induced acute kidney; injury; meta-analysis; Percutaneous coronary intervention; prognosis; systemic immune inflammation index

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