Current Topics in Medicinal Chemistry - Volume 21, Issue 17, 2021

Tea, a worldwide popular beverage rich in polyphenols, contributes to the prevention of many diseases and thus is beneficial to human health. Tea is a product through processing the fresh leaves picked from the plant Camellia sinensis (C. sinensis, genus Camellia section Thea). To date, systematic studies have been conducted on the phytochemicals from more than 20 tea varieties and related tea products, resulting in t Read More

Since a variety of benzo-fused nitrogen- and oxygen-based bioactive heterocyclic moieties are present in the form of benzoxazinones, spirooxindole-based heterocyclic compounds, coumarinfused heterocyclic compounds, and 2H-indazoles, this review article briefly describes some of the major advancements and developments in the area of 1,4-benzoxazine-3-ones, 1,4-benzoxazin-2- ones, spiropyrrolidine and spiro Read More

Plant-endophyte associations represent an inexhaustible source of novel metabolites, exhibiting significance in environment, agriculture and pharmaceutical perspectives. The global outbreak of life-threatening diseases necessitates a need for a more targeted approach through efficient drug-discovery programs. In recent times, endophytes as “bio-factories” have been extensively explored for the production of novel bio Read More

Tetrahydroquinoline and isoquinoline scaffolds are important class of heterocyclic compounds, which is implied for the development of new drugs and diagnostic for therapeutic function. Naturally occurring as well as synthetic tetrahydroquinolines/isoquinolines possess many different biological activities and have been testified as remarkable cytotoxic and potency in human cancer cell lines. Tetrahydroquinoline/isoquinoline base Read More