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- Volume 14, Issue 4, 2014
Current Topics in Medicinal Chemistry - Volume 14, Issue 4, 2014
Volume 14, Issue 4, 2014
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Editorial (Thematic Issue: Natural & Synthetically-Modified Cyclodextrins and Polymers in Drug Delivery Systems)
Authors: Francisco J. Otero-Espinar and Jose Blanco-MendezCyclodextrins are natural cyclic oligosaccharides that play a relevant role in different fields as pharmacy, medicine, chemistry, material, food or agricultural science. From the point of view of pharmaceutical and medical applications cyclodextrins have interest for their ability to form inclusion complexes with different host molecules as drugs. In the pharmaceutical industry, cyclodextrins has been used classically as solubilizes o Read More
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Cyclodextrin/Dendrimer Conjugates as DNA and Oligonucleotide Carriers
Authors: Hidetoshi Arima, Keiichi Motoyama and Taishi HigashiRecently, various cyclodextrin (CyD)-grafted polymers and supramolecules have been developed as gene and oligonucleotide carriers. We have demonstrated that among the various polyamidoamine starburstTM dendrimers (dendrimers) conjugates with CyDs (CDEs), the dendrimer (G2 or G3) conjugate with α-CyD showed high gene and oligonucleotide transfer activity with negligible cytotoxicity. In addition, to develop tissu Read More
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Cyclodextrin Based Rotaxanes, Polyrotaxanes and Polypseudorotaxanes and their Biomedical Applications
For years, great efforts have been made by scientists to construct various novel interlocked supramolecular systems. A wide range of pseudorotaxanes and rotaxanes [1-7], full of challenging constructions and potential applications in areas such as nanostructured functional materials [8,9], molecular switches [10-14], molecular logic gates [15-19], molecular wires [20-22], memory devices Willner [23] and bio Read More
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Syringeable Self-Assembled Cyclodextrin Gels for Drug Delivery
The design of syringeable cyclodextrin (CD) gels is a developing area in the drug delivery and tissue engineering fields, since they offer the possibility of being administered with minimally invasive maneuvers to form depots that can remain for prolonged time in the implantation site. Two different supramolecular systems can be obtained exploiting the capability of CDs to form inclusion complexes. (i) The threading of free Read More
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Oil-Cyclodextrin Based Beads for Oral Delivery of Poorly-Soluble Drugs
Authors: M.C. Hamoudi and A. BochotThe main interest of cyclodextrins results from their ability to form inclusion complexes with hydrophobic molecules. This property is employed in pharmaceutical industry to facilitate the formulation of poorly-soluble and/or fragile drugs. Cyclodextrins are also used to form or stabilise dispersed systems. An original multiparticulate system named “beads” is obtained thanks to the interactions occurring between the mol Read More
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Cyclodextrin Inclusion Complexes Loaded in Particles as Drug Carrier Systems
Authors: Leonardo Fernandes Fraceto, Renato Grillo and Eduardo Sobarzo-SanchezThis mini-review paper does not consider classical work concerning the formation of inclusion complexes between pharmaceuticals and cyclodextrins. Instead, it highlights recent reports concerning the association of these host:guest systems with other carrier systems such as liposomes and nanoparticles showing the state of art of this subject with examples of developed systems and the advantages of these st Read More
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Progress in Developing Amphiphilic Cyclodextrin-Based Nanodevices for Drug Delivery
Nowadays, colloidal drug carriers represent an alternative to solve drug bioavailabily problems. During the past two decades, colloidal drug carriers have proved to improve the therapeutic index of drugs and thus increase their efficacy and/or reduce their toxicity. However, the major challenge in the development of these drug carriers remains the search for materials able to self-organize into stable nanoscale systems. In partic Read More
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Cyclodextrin-Based Polysaccharidic Polymers: An Approach for the Drug Delivery
The aim of the present review is to give an overview of a new class of polysaccharidic CD-based systems and to address the use of these systems in drug delivery. First, we review miscellaneous methods to obtain and synthesize the structural modification of natural polysaccharides, mainly, with cyclodextrins. In a second part of this review, we provide a summary of recent findings not only in the field of drug delivery, but in a Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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