Current Stem Cell Research & Therapy - Volume 12, Issue 8, 2017

Background: Adult mesenchymal stem cells (MSCs) were first isolated from bone marrow by Friedenstein in 1976. These cells were clonogenic, non-haematopoietic, and able to replicate extensively in vitro. The fields of regenerative medicine and tissue engineering have grown dramatically since their inception. In the decades since, MSCs have been identified from mesoderm-, endoderm- and ectoderm-derived tissues. In light of Read More

Background: Diabetes mellitus, the widely prevalent disease of pancreas, is a metabolic disorder caused by autoimmune destruction of β cells or insulin insufficiency or insulin resistance. Replacement of damaged β cells by cell therapy can mitigate the condition and re-establish normal metabolic control. This has opened up new horizons for research, such as stem cells, cellular reprogramming and β cell regeneration. O Read More

Background: Despite optimal treatment, myocardial infarction (MI) remains a major cause of death worldwide. Stem cell transplantation, as a promising therapy hoping to improve myocardial function and generate new myocardium, has been intensely studied for treating MI. Objective: To summarize the recent advance of stem cell transplantation for treating MI in clinical trials and preclinical studies. Results: Several types Read More

Background: Embryonic stem cells are pluripotent, meaning they have the capacity to selfrenew and to differentiate into cells of the 3 germ layers. In 2006, Takahashi et al. reprogrammed somatic cells into stem cells using exogenetic gene expression. These new cells became known as induced pluripotent stem cells (iPSCs). Research continues to develop new tools and techniques in order to reprogram cells with higher output an Read More

Background: Inflammatory bowel diseases (IBD), which include Crohn's disease and Ulcerative Colitis, are inflammatory autoimmune diseases which severely affect the quality of life. Till date, no long-lasting cure has been found for the disease and all the current treatment strategies are mainly focused on dampening the symptomatic inflammatory process that has certain side effects. In addition, a large number of patien Read More

Background: During the last two decades, a number of studies have been carried out on the application of regenerative medicine in the field of dermatology. Objective: The aim of this research was to critically review the application of regenerative medicine in the field of dermatology. The next aim was to look in depth to see whether regenerative medicine strategies have a place in the future of wound healing in a clinical s Read More

Background: Fibroblasts are the common cells used in clinical regenerative medicine and dentistry. These cells are known to appear heterogeneous in vivo. Previous studies have only investigated the biological properties of these cell subpopulations in vitro. Despite sharing similarity in their spindle-shaped appearance, previous literatures revealed that they play distinguished functional and biological activities in the body. Obj Read More