Current Regenerative Medicine (Discontinued) - Volume 6, Issue 1, 2016

Acute and chronic kidney diseases represent an emerging problem in management and costs of healthcare. Understanding the mechanisms responsible for injury and repair is the mainstay to a more precise classification and staging thus envisioning potential strategies of intervention. Experimental models of acute kidney disease and chronic kidney disease are important even if necessarily artefactual to having a deep i Read More

Induction of donor-specific immunological tolerance in order to eliminate the lifelong systemic immunosuppressive therapy and their deleterious side effects as well as to prevent graft loss due to acute or chronic rejection or drug toxicity has been considered the "Holy Grail" of transplantation. The only effective approach of inducing tolerance is combined organ (e.g. kidney) and donor bone marrow transplantation. The hallmar Read More

Background: Leishmania parasites causative agents of leishmaniasis are aerotolerant or microaerophilic and consume oxygen to some extent. Leishmania parasites produce hydrogen peroxide as a metabolism product in certain circumstances and are naturally exposed to the toxin metabolites such as Reactive Oxygen Species generated by macrophages. To stand oxidative stress, trypanosomatids evolved a unique Read More

Background: In recent years, tissue engineering (TE) and regenerative medicine (RM) are rapidly evolving fields. TE and RM are part of the biomedical field, and both are emergent research areas with a high impact on medical issues. The development of new types of novel, effective and highly reliable engineering constructs is essential to tackle many human health-related diseases. To this end, materials science tech Read More

Background: Platelet rich plasma is one of the simplest regenerative medicine method used to deliver growth factors and other substances at the desired areas in higher concentrations. PRP is proved to help in tissue regeneration and augments tissue healing. It is being used in variety of conditions in many surgical and medical conditions. There are multiple commercially available preparation kits which vary in terms of dif Read More

Background: Human microRNAs (miRs) that have been evaluated toward medical application are largely the early-introduced sequences numbered below 1000, with GC content close to Drosophila melanogaster fruitfly, but rather below current averages for human miRs. The research bias toward low database numbers and low GC content is found for all sectors of human miRs. Objective: Characterization of all human miRs Read More