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Use of CRISPR in Infection Control
- Source: Current Protein and Peptide Science, Volume 23, Issue 5, May 2022, p. 299 - 309
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- 01 May 2022
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Abstract
One of the greatest threats to the global world is infectious diseases. The morbidity and fatality of infectious diseases cause 17 million deaths annually. The recent COVID-19 pandemic describes the uncertain potential of these diseases. Understanding the pathogenesis of infectious agents, including bacteria, viruses, fungi, etc. and the evolution of rapid diagnostic techniques and treatments has become a pressing priority to improve infectious disease outcomes worldwide. Clustered regularly interspaced short palindromic repeats (CRISPR) constitute the adaptive immune system of archaea and bacteria along with CRISPR-associated (Cas) proteins that recognize and destroy foreign DNA acting as molecular scissors. Since their discovery, CRISPR systems are classified into 6 types and 22 subtypes. Type II, V, and VI are used for diagnostic purposes. Utilizing the CRISPR-Cas system's capabilities will aid promote the development of novel and improved diagnostics as well as innovative delivery systems and the prevention and treatment of infectious diseases.