Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 7, Issue 3, 2009

We are pleased to introduce the September issue of Current Pharmacogenomics and Personalized Medicine (CPPM) and share with you the editorial vision of the Journal as an integrated new title addressing both pharmacogenomics and personalized medicine readership effective 2008. CPPM has a unique focus on the complex challenges and promises emerging from the fusion of knowledge domains in therapeutics and diagnostic Read More

Unprecedented advances in the genomic sciences have arrived “just in time” to help alleviate a daunting spectrum of health problems in the developing world ranging from tropical infectious diseases to non-communicable diseases to the health impacts of globalization. Pharmacogenomics and personalized medicine, applied judiciously, ethically and in the context of developing world needs and realities, Read More

Muin J. Khoury, MD, PhD is the first and current director of the Office of Public Health Genomics at the Centers for Disease Control and Prevention (CDC) in the United States. The Office was formed in 1997 to assess the impact of advances in human genetics and the Human Genome Project on public health and disease prevention. As an internationally recognized institution, CDC's mission is to protect the health and safety of pe Read More

Objective: Transcriptomic biomarkers of psychiatric diseases obtained from a query of peripheral tissues that are clinically accessible (e.g., blood cells instead of post-mortem brain tissue) have substantial practical appeal to discern the molecular subtypes of common complex diseases such as major psychosis. To this end, spliceome-profiling is a new methodological approach that has considerable conceptual relevance for disco Read More

While human nutrigenomics research and efforts for targeted nutritional interventions intensified over the past few years, there are fundamental lessons to be learned from Drosophila and evolutionary biology for human nutrient-gene interactions. With the advent of inexpensive whole genome sequencing, single-nucleotide polymorphisms (SNPs) and insertions-deletions (INDELs) can now be associated with specific nutri Read More

Nutrigenomics covers disparate fields of nutrition science and has been defined in many different ways. In fact, this emerging field of science has multiple facets, many of which do not generate the same ethical issues. In particular, different ethical issues emerge concerning the extent to which nutrigenomics may actually improve global health, i.e., in terms of worldwide improvement of health, reduction of disparities, and Read More

Diabetic retinopathy is a leading cause of blindness in the Western world. However, treatment options for diabetic retinopathy are limited and display poor efficacy with marked patient-to-patient variation in therapeutic outcomes. Discovery of new molecular entities acting on mechanistically novel biological pathways remains as one of the key research priorities in diabetic retinopathy. Moreover, given the varia Read More

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