Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 14, Issue 1, 2016

Drugs are generally tested on a large population of people via phase studies and the average response is reported in a sort of evidence-based medicine. Screening of genetic variations is necessary in understanding the underlying mechanisms of individual drug responses and to find out more targeted and unique therapeutic strategies focusing on this individual variations. The “-omics” (genomics/proteomics/metabolomic Read More

Background: Practical challenges and translational issues have affected the widespread implementation of pharmacogenomics and personalized medicine. There are significant barriers to the translation of personalized medicine from research labs to practical application in a healthcare setting. Methods: The information in this review paper was collected via search engines and Pub- Med using the following search entries Read More

DNA polymorphisms have an important role in the genes encoding. A number of cytochrome P450 (CYP) enzymes are leading to drug metabolism variation in different subjects. CYP2C9 and CYP2C19 metabolize many clinically important drugs. Inter-individual variability in drug metabolism may change drug reactions and variability in drug efficiency. Cytochrome P450 (CYPs) polymorphisms may show an important effect on drug Read More

The employment of comet assay has gained wide importance in various areas that focus on human bio-monitoring, genetic toxicology, molecular epidemiology and ecogenotoxicity. Comet assay has become among the standard methods for evaluating genotoxicity by the determination of DNA damage caused by mutagens, and this assay has been extensively applied by the researchers for the past 20 years. This review discuss Read More

Background: With the use of next generation sequencing technologies, translational research is becoming a catalyst for the implementation of personalized medicine (PM). To implement PM, we will also need to ensure that sensitive results are shared, used and returned to the participants in compliance with applicable ethical and legal frameworks. Furthermore, the increasingly blurred distinction between research and clinical Read More

Background: It is known that the distribution of polymorphism frequencies can vary greatly between different ethnic groups, resulting in variable percentages of poor, intermediate or extensive metabolizers in a given population. Objective: This study was carried out to estimate the genotype frequencies of common variants in the CYP2D6, CYP3A5 and DPYD genes in the Yakut population from North-Eastern Siberia. To compar Read More

Background: The drug response varies from person to person. The possibility for the drugs to move to a large number of bio molecular targets and lack of personalization are the major reasons for this. The multi targeting of drugs and resulted drug resistance and side effects can be minimized by designing and developing personalized drugs. Retro metabolic design strategy helps in generating promising molecules with less toxic Read More