Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 11, Issue 2, 2013

In 1996, the US-based biotechnology company Myriad Genetics began offering genetic diagnostic tests for mutations in the genes BRCA1 and BRCA2, which are linked to hereditary breast and ovarian cancer. Since that time, Myriad has been a forerunner in the field of personalized medicine through the use of effective commercialization strategies which have been emulated by other commercial biotechnology com Read More

The dopaminergic system has an important role in the rewarding properties of nicotine. Gene polymorphisms of DRD2 and DβH that regulate dopamine neurotransmission or metabolism could influence smoking behavior. Additionally, the ability of a 5-HT2CR agonist to block mesolimbic dopamine activation produced by nicotine at the level of ventral tegmental area, suggests a possible interaction between dopaminergic Read More

Gliomas are the most common form of brain tumor, originate from glial cells and characterized by rapidly proliferating cells frequently associated with an invasive phenotype. Several focused studies have successfully demonstrated the genetic origin of these tumors; however, a systems level study to provide comprehensive overview of complex molecular alterations associated with glioma pathogenesis is essential. In this stud Read More

Medulloblastomas are the most aggressive pediatric brain tumors originating from self-renewing common progenitor cells and associated with high rate of invasion along with rapid spread. The hereditary origin of these tumors can be studied to define it at genome level; however, to understand the molecular mechanism and pathogenesis, systems level investigation is required. In this study we used systems level analysis to ident Read More

This study was designed to determine the effect of CYP2C19 polymorphisms on platelet response in patients with atherothrombotic-risks receiving clopidogrel treatment. Ninety-five antiplatelet naive atherothrombotic-risk patients were enrolled consecutively. Clopidogrel at 75 mg/day was administered for 2 weeks, followed by a platelet function test (PFT). Non-responders were identified and randomized for receiving either Read More

Food has societal, economic, medical and ethical implications, being fundamental for life. It plays an important role also in sports medicine, since a healthy diet is an important part of an athlete's training. Nutrigenomics and nutriproteomics are emerging as a result of a convergence of nutritional, genomics and proteomics knowledge strands in the postgenomics era. These fields of inquiry present an opportunity for the Read More

Nutrigenomics and nutrigenetics are receiving growing attention from a diverse range of stakeholders including health care professionals, citizens, governments, insurers and industry. Currently there is special focus on research on how our food influences us and might cause discomfort or even symptoms of disease, but also the fact that several food intolerances are caused by genetic alterations. The strong interest expressed b Read More