Skip to content
2000
Volume 27, Issue 20
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Aim: The present work provides a fast, simple, accurate, and inexpensive analytical method for the determination of Linagliptin (anti-diabetic drug). Methods: The analysis was performed using a square wave adsorptive anodic stripping voltammetric technique (SWAASV) and glassy carbon electrode (GCE) as a working electrode. The experimental and instrumental parameters were studied and discussed to ensure the validity of the method. Results: The method has a very good linearity (R2 = 0.9984), wide concentration range (0.189 - 2.268 μg mL-1), low detection limit of 0.052 μg mL-1 and low quantitation limit of 0.172 μg mL-1. Conclusion: Linagliptin was identified successfully using the proposed method in pharmaceutical formulations, spiked human urine and plasma with 99.67, 91.96, and 92.78% recovery, respectively, and the results obtained were compared with other reported methods.

Loading

Article metrics loading...

/content/journals/cpd/10.2174/1381612826666200925123245
2021-06-01
2025-07-03
Loading full text...

Full text loading...

/content/journals/cpd/10.2174/1381612826666200925123245
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test